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Interaction of the Natural Anti-Gal Antibody with Alpha-galactosyl Epitopes: a Major Obstacle for Xenotransplantation in Humans

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Journal Immunol Today
Date 1993 Oct 1
PMID 7506033
Citations 118
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Abstract

Cells of nonprimate mammals express an abundance of the carbohydrate structure Gal alpha 1-3 Gal beta 1-4 GlcNac-R (termed the alpha-galactosyl epitope). The natural anti-Gal antibody, which interacts specifically with alpha-galactosyl epitopes, is present in high concentrations in all humans. Here, Uri Galili argues that the interaction between anti-Gal in the serum and alpha-galactosyl epitopes on cells of nonprimate grafts may act as an immunological barrier which prevents xenotransplantation.

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