Differential Sensitivities of Five Rat Hepatoma Cell Lines to Anticancer Drugs

Overview

Journal Cancer Res

Specialty Oncology

Date 1978 Mar 1

PMID 75057

Citations 10

Authors

S C Barranco

B R Haenelt

E L Gee

Affiliations

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Abstract

Five permanent tumor cell lines derived originally from either a solid or an ascites biopsy of rat hepatoma exhibited differential sensitivities to bleomycin, Adriamycin, 1-beta-D-arabinofuranosylcytosine, hydroxyurea, 1-trans-(2)-chloroethyl)-3-(4-methoylcyclohexyl)-1-nitrosourea, and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. The cells were least sensitive to hydroxyurea and 1-beta-D-arabinofurano-sylcytosine, with some cell lines being almost totally resistant to these drugs. However, from 25- to 700-fold differences in survival were obtained between cell lines treated with either bleomycin or Adriamycin.

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