The Renal Nerves in the Newborn Rat

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1993 Oct 1

PMID 7504502

Citations 3

Authors

L BARAJAS

L Liu

Affiliations

Soon will be listed here.

Abstract

Immunocytochemical methods were used to investigate the distribution of afferent [calcitonin gene-related peptide-(CGRP) immunoreactive and substance P-immunoreactive] nerves and efferent (neuropeptide Y-immunoreactive and dopamine beta-hydroxylase-immunoreactive) nerves in the kidneys of rats within the 1st day of life. The newborn rat kidney possesses an afferent and efferent innervation. Both afferent and efferent nerves reach the kidney in the same bundles. The afferent sensory fibers predominate overwhelmingly in the renal pelvis and ureter while the efferent fibers clearly predominate in the vasculature. The corticomedullary connective tissue contains both types of innervation with a more prominent afferent innervation (CGRP immunoreactive). Only afferent arterioles of perihilar nephrons were innervated by efferent sympathetic fibers. The distribution and extent of afferent and efferent innervation is consistent with the renal nerves playing a significant role in the transition from fetal to newborn life. The close proximity between afferent and efferent fibers suggests a possible interaction between the two systems.

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References

Smith F, Smith B, Guillery E, Robillard J . Role of renal sympathetic nerves in lambs during the transition from fetal to newborn life. J Clin Invest. 1991; 88(6):1988-94. PMC: 295784. DOI: 10.1172/JCI115525. View

McKenna O, Angelakos E . Development of adrenergic innervation in the puppy kidney. Anat Rec. 1970; 167(1):115-25. DOI: 10.1002/ar.1091670111. View

Ballesta J, Polak J, Allen J, Bloom S . The nerves of the juxtaglomerular apparatus of man and other mammals contain the potent peptide NPY. Histochemistry. 1984; 80(5):483-5. DOI: 10.1007/BF00495438. View

Allen J, Raine A, LEDINGHAM J, Bloom S . Neuropeptide Y: a novel renal peptide with vasoconstrictor and natriuretic activity. Clin Sci (Lond). 1985; 68(4):373-7. DOI: 10.1042/cs0680373. View

Lundberg J, Anggard A, Pernow J, Hokfelt T . Neuropeptide Y-, substance P- and VIP-immunoreactive nerves in cat spleen in relation to autonomic vascular and volume control. Cell Tissue Res. 1985; 239(1):9-18. DOI: 10.1007/BF00214896. View

Kurtz A, Muff R, Fischer J . Calcitonin gene products and the kidney. Klin Wochenschr. 1989; 67(17):870-5. DOI: 10.1007/BF01717342. View

Slotkin T, Levant B, Queen K, Stasheff S . Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins. J Pharmacol Exp Ther. 1988; 244(1):166-72. View

Westfall T, Chen X, Ciarleglio A, Henderson K, del Valle K, Naes L . In vitro effects of neuropeptide Y at the vascular neuroeffector junction. Ann N Y Acad Sci. 1990; 611:145-55. DOI: 10.1111/j.1749-6632.1990.tb48928.x. View

Reinecke M, Forssmann W . Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves. Histochemistry. 1988; 89(1):1-9. DOI: 10.1007/BF00496578. View

10.

Kopp U, Smith L, Dibona G . Facilitatory role of efferent renal nerve activity on renal sensory receptors. Am J Physiol. 1987; 253(4 Pt 2):F767-77. DOI: 10.1152/ajprenal.1987.253.4.F767. View

11.

Lundberg J, Pernow J, Tatemoto K, Dahlof C . Pre- and postjunctional effects of NPY on sympathetic control of rat femoral artery. Acta Physiol Scand. 1985; 123(4):511-3. DOI: 10.1111/j.1748-1716.1985.tb07619.x. View

12.

BARAJAS L, Liu L, Nishiyama C . Prenatal and postnatal development of the CGRP-immunoreactive innervation in the rat kidney. Neurosci Lett. 1991; 133(2):219-24. DOI: 10.1016/0304-3940(91)90574-d. View

13.

Moss N . Electrophysiological characteristics of renal sensory receptors and afferent renal nerves. Miner Electrolyte Metab. 1989; 15(1-2):59-65. View

14.

Slotkin T, Lau C, Kavlock R, Gray J, Queen K, Baker F . Role of sympathetic neurons in biochemical and functional development of the kidney: neonatal sympathectomy with 6-hydroxydopamine. J Pharmacol Exp Ther. 1988; 246(2):427-33. View

15.

Kawasaki H, Nuki C, Saito A, Takasaki K . Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel. Brain Res. 1990; 506(2):287-90. DOI: 10.1016/0006-8993(90)91263-g. View

16.

Page W, Perlman S, Smith F, Segar J, Robillard J . Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. Am J Physiol. 1992; 262(3 Pt 2):R459-63. DOI: 10.1152/ajpregu.1992.262.3.R459. View

17.

Ferguson M, Bell C . Ultrastructural localization and characterization of sensory nerves in the rat kidney. J Comp Neurol. 1988; 274(1):9-16. DOI: 10.1002/cne.902740103. View

18.

Casellas D, Navar L . In vitro perfusion of juxtamedullary nephrons in rats. Am J Physiol. 1984; 246(3 Pt 2):F349-58. DOI: 10.1152/ajprenal.1984.246.3.F349. View

19.

Maggi C, Theodorsson E, Santicioli P, Giuliani S . Tachykinins and calcitonin gene-related peptide as co-transmitters in local motor responses produced by sensory nerve activation in the guinea-pig isolated renal pelvis. Neuroscience. 1992; 46(3):549-59. DOI: 10.1016/0306-4522(92)90143-p. View

20.

Marfurt C, Echtenkamp S . Sensory innervation of the rat kidney and ureter as revealed by the anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from dorsal root ganglia. J Comp Neurol. 1991; 311(3):389-404. DOI: 10.1002/cne.903110309. View