Regulation of Insulin-like Growth Factor-I (IGF-I) and IGF-binding Proteins by Tumor Necrosis Factor
Overview
Authors
Affiliations
The purpose of the present study was to determine 1) whether exogenous administration of tumor necrosis factor-alpha (TNF-alpha) alters insulin-like growth factor-I (IGF-I) and IGF-binding proteins (BPs) and 2) whether the enhanced endogenous production of TNF mediates the lipopolysaccharide (LPS)-induced changes in the IGF system. The overnight infusion of murine TNF-alpha reduced circulating concentrations of both growth hormone (GH) and IGF-I in fasted rats. Furthermore, TNF-alpha decreased IGF-I content in liver, gastrocnemius muscle, and pituitary. In contrast, TNF-alpha increased IGF-I content in kidney and brain. IGFBP-1 was increased in plasma, liver, and muscle in response to TNF-alpha. In a second study, rats were injected with LPS after treatment with a neutralizing anti-TNF antibody (Ab), and blood and tissues were collected 4 h later. In LPS-treated rats, plasma concentrations of GH and IGF-I were reduced. LPS also decreased the IGF-I content in liver and skeletal muscle and increased plasma, liver, and muscle concentrations of IGFBP-1. Pretreatment with anti-TNF Ab attenuated the LPS-induced reduction in IGF-I and the increased IGFBP-1 in plasma and liver and completely prevented the decrease in IGF-I observed in muscle. In contrast, the LPS-induced decrease in plasma GH and the increased IGFBP-1 observed in muscle were unaltered by the anti-TNF Ab.(ABSTRACT TRUNCATED AT 250 WORDS)
Dowery R, Benhamou D, Benchetrit E, Harel O, Nevelsky A, Zisman-Rozen S Blood. 2021; 138(19):1817-1829.
PMID: 34297797 PMC: 9642783. DOI: 10.1182/blood.2021012428.
Reis L, Ramos-Sanchez E, Araujo F, Leal A, Ozaki C, Sevillano O J Immunol Res. 2021; 2021:6614475.
PMID: 34036108 PMC: 8116165. DOI: 10.1155/2021/6614475.
A case of ulcerative colitis associated with teprotumumab treatment for thyroid eye disease.
Safo M, Silkiss R Am J Ophthalmol Case Rep. 2021; 22:101069.
PMID: 33817409 PMC: 8008157. DOI: 10.1016/j.ajoc.2021.101069.
de Pinho F, Vendrame C, Maciel B, Silva L, Miyashiro S, Jeronimo S Am J Trop Med Hyg. 2019; 100(4):808-815.
PMID: 30761980 PMC: 6447109. DOI: 10.4269/ajtmh.17-0982.
Leviton A, Allred E, Fichorova R, VanderVeen D, OShea T, Kuban K Am J Perinatol. 2019; 36(14):1442-1452.
PMID: 30685870 PMC: 7252600. DOI: 10.1055/s-0038-1677472.