High-level Quinolone Resistance in Neisseria Gonorrhoeae: a Report of Two Cases

Overview

Journal Sex Transm Dis

Specialty Infectious Diseases

Date 1995 Sep 1

PMID 7502185

Citations 10

Authors

J W Tapsall

E A Limnios

C Thacker

B Donovan

S D Lynch

L J KIRBY

K A Wise

C J Carmody

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported.

Study Design: This is a case report.

Conclusion: High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.

Citing Articles

Antimicrobial resistance in Neisseria gonorrhoeae: history, molecular mechanisms and epidemiological aspects of an emerging global threat.

Ramalho da Costa-Lourenco A, Barros Dos Santos K, Moreira B, Fracalanzza S, Bonelli R Braz J Microbiol. 2017; 48(4):617-628.

PMID: 28754299 PMC: 5628311. DOI: 10.1016/j.bjm.2017.06.001.

Epitope determination of immunogenic proteins of Neisseria gonorrhoeae.

O Connor D, Danckert L, Hoppe S, Bier F, von Nickisch-Rosenegk M PLoS One. 2017; 12(7):e0180962.

PMID: 28723967 PMC: 5516995. DOI: 10.1371/journal.pone.0180962.

High prevalence of high-level ciprofloxacin resistance in Neisseria gonorrhoeae in Tel Aviv, Israel: correlation with response to therapy.

Dan M, Poch F, Sheinberg B Antimicrob Agents Chemother. 2002; 46(6):1671-3.

PMID: 12019074 PMC: 127211. DOI: 10.1128/AAC.46.6.1671-1673.2002.

Antibiotic susceptibility patterns of Neisseria meningitidis isolates from patients and asymptomatic carriers.

Arreaza L, de la Fuente L, Vazquez J Antimicrob Agents Chemother. 2000; 44(6):1705-7.

PMID: 10817734 PMC: 89938. DOI: 10.1128/AAC.44.6.1705-1707.2000.

Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998.

Tanaka M, Nakayama H, Haraoka M, Saika T J Clin Microbiol. 2000; 38(2):521-5.

PMID: 10655338 PMC: 86137. DOI: 10.1128/JCM.38.2.521-525.2000.