Caenorhabditis Elegans Mutants Resistant to Inhibitors of Acetylcholinesterase

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1995 Jun 1

PMID 7498734

Citations 99

Authors

M Nguyen

A Alfonso

C D Johnson

J B Rand

Affiliations

Soon will be listed here.

Abstract

We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.

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