Down-regulation of Mitochondrial MRNAs in the Mdx Mouse Model for Duchenne Muscular Dystrophy

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1995 Nov 20

PMID 7498514

Citations 13

Authors

S Fournier-Bidoz

G Le Cam

C Chambon

P Millasseau

J J Leger

C A Dechesne

Affiliations

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Abstract

In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice.

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