Posttranslational Signal Peptidase Cleavage at the Flavivirus C-prM Junction in Vitro

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Dec 1

PMID 7494334

Citations 19

Authors

C E Stocks

M Lobigs

Affiliations

Soon will be listed here.

Abstract

We have investigated the cleavages at the flavivirus capsid-prM protein junction in vitro. When expressed in the absence of the flavivirus proteinase, capsid and prM, which are separated by an internal signal sequence, exist as a membrane-spanning precursor protein. Here we show the induction of posttranslational signal peptidase cleavage of prM by trypsin cleavage of a cytoplasmic region of this precursor protein.

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