Cerebrospinal Fluid Zinc Concentrations in Febrile Convulsions

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1995 Oct 1

PMID 7492199

Citations 5

Authors

B Z Garty

R Olomucki

T Lerman-Sagie

M Nitzan

Affiliations

Soon will be listed here.

Abstract

Zinc modulates the activity of glutamic acid decarboxylase, the rate limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter. Low cerebrospinal fluid GABA values have been reported in association with several seizure disorders, including febrile convulsions. It is also known that fever and/or infections may cause a reduction in serum zinc concentrations. In this study the hypothesis that febrile convulsions are related to low cerebrospinal fluid zinc was tested. Cerebrospinal fluid zinc concentrations were measured in 66 febrile children: 32 with febrile convulsions, 18 with fever but without convulsions, and 16 with aseptic (viral) meningitis. There was no statistically significant difference in the cerebrospinal fluid zinc between the three groups of children, and the mean concentration was 26.2 micrograms/l. No significant relationship was found between either age, gender, maximal temperature, type of infection, or time of performance of the lumbar puncture and cerebrospinal fluid zinc concentration. These results do not support the hypothesis that febrile convulsions are related to reduced cerebrospinal fluid zinc concentrations.

Citing Articles

Comparison of Serum Zinc Levels among Children with Simple Febrile Seizure and Control Group: A Systematic Review.

Nasehi M, Sakhaei R, Moosazadeh M, Aliramzany M Iran J Child Neurol. 2015; 9(1):17-24.

PMID: 25798166 PMC: 4357343.

Zinc status in febrile seizure: a case-control study.

Salehiomran M, Mahzari M Iran J Child Neurol. 2014; 7(4):20-3.

PMID: 24665313 PMC: 3943049.

Serum Zinc Level in Children Presenting with Febrile Seizures.

Rabbani M, Ali I, Zahid Latif H, Basit A, Rabbani M Pak J Med Sci. 2013; 29(4):1008-11.

PMID: 24353677 PMC: 3817762.

Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures.

Lee J, Kim J Ann Lab Med. 2012; 32(3):190-3.

PMID: 22563553 PMC: 3339298. DOI: 10.3343/alm.2012.32.3.190.

Zinc in CSF of patients with febrile convulsion.

Mollah M, Dey P, Tarafdar S, Akhter S, Ahmed S, Hassan T Indian J Pediatr. 2002; 69(10):859-61.

PMID: 12450294 DOI: 10.1007/BF02723706.

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