Expression of Alpha-fetoprotein by Ovarian Sertoli-Leydig Cell Tumors. Case Report and Review of the Literature

Overview

Journal Arch Pathol Lab Med

Specialty Pathology

Date 1995 Nov 1

PMID 7487411

Citations 6

Authors

A Hammad

K M Jasnosz

P R Olson

Affiliations

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Abstract

A 17-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly spindled cellular stroma containing open and solid tubules, focal clusters of hepatoid cells, and heterologous carcinoid. Alpha-fetoprotein was demonstrated within the hepatoid cells by immunohistochemical techniques. After surgery, serum alpha-fetoprotein level fell to normal, and the patient is still free of tumor 8 months later.

Citing Articles

15-Year-Old Patient with an Unusual Alpha-Fetoprotein-Producing Sertoli-Leydig Cell Tumor of Ovary.

Serife K, Karampelas S, Hottat N, Devalck C, Houte K Case Rep Obstet Gynecol. 2022; 2022:4759826.

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Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review.

Horta M, Cunha T, Canas Marques R, Felix A J Radiol Case Rep. 2015; 8(11):30-41.

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Gastric choriocarcinoma admixed with an alpha-fetoprotein-producing adenocarcinoma and separated adenocarcinoma.

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