Toxoplasmosis and Primary Central Nervous System Lymphoma in HIV Infection: Diagnosis with MR Spectroscopy

Overview

Journal Radiology

Specialty Radiology

Date 1995 Dec 1

PMID 7480733

Citations 15

Authors

R J Chinn

I D Wilkinson

M A Hall-Craggs

M N Paley

R F Miller

B E Kendall

S P Newman

M J Harrison

Affiliations

Soon will be listed here.

Abstract

Purpose: To differentiate intracranial lymphoma from Toxoplasma gondii lesions in patients infected with the human immunodeficiency virus, by means of localized spin-echo proton magnetic resonance (MR) spectroscopy.

Materials And Methods: Twenty-seven lesions were studied (18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were acquired at an echo time of 135 msec from voxels centered on the lesions. Both visual analysis and spectral fitting were used to obtain metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA), lactate, and lipids.

Results: Three spectral categories were seen. One had large lipid peaks with suppression of other metabolites. Another had an elevated Cho/Cr ratio with relatively diminished NA. The third had features of the other two. Examples of each spectrum type were acquired from both T gondii and lymphoma lesions. Neither method of analysis allowed differentiation between lesion types. MR spectroscopy showed an overlap of spectra.

Conclusion: The authors conclude that toxoplasmosis and lymphoma cannot be differentiated with spin-echo proton MR spectroscopy at 135 msec.

Citing Articles

MRI imaging features of HIV-related central nervous system diseases: diagnosis by pattern recognition in daily practice.

Sakai M, Higashi M, Fujiwara T, Uehira T, Shirasaka T, Nakanishi K Jpn J Radiol. 2021; 39(11):1023-1038.

PMID: 34125369 PMC: 8202053. DOI: 10.1007/s11604-021-01150-4.

Diagnostic accuracy of SPECT, PET, and MRS for primary central nervous system lymphoma in HIV patients: A systematic review and meta-analysis.

Yang M, Sun J, Bai H, Tao Y, Tang X, States L Medicine (Baltimore). 2017; 96(19):e6676.

PMID: 28489744 PMC: 5428578. DOI: 10.1097/MD.0000000000006676.

Neuropathological correlate of the "concentric target sign" in MRI of HIV-associated cerebral toxoplasmosis.

Mahadevan A, Ramalingaiah A, Parthasarathy S, Nath A, Ranga U, Krishna S J Magn Reson Imaging. 2013; 38(2):488-95.

PMID: 23440973 PMC: 4442780. DOI: 10.1002/jmri.24036.

A review on the clinical uses of SPECT/CT.

Mariani G, Bruselli L, Kuwert T, Kim E, Flotats A, Israel O Eur J Nucl Med Mol Imaging. 2010; 37(10):1959-85.

PMID: 20182712 DOI: 10.1007/s00259-010-1390-8.

Oral administration of choline does not affect metabolic characteristics of gliomas and normal-appearing white matter, as detected with single-voxel (1)H-MRS at 1.5 T.

Chernov M, Muragaki Y, Maruyama T, Ono Y, Usukura M, Yoshida S Neuroradiology. 2008; 51(3):137-43.

PMID: 18949472 DOI: 10.1007/s00234-008-0471-x.