Detection of Cytomegalovirus and Epstein-Barr Virus in Labial Salivary Glands in Sjogren's Syndrome and Non-specific Sialadenitis

Overview

Journal J Oral Pathol Med

Specialties Dentistry
Pathology

Date 1995 Aug 1

PMID 7473264

Citations 13

Authors

N Maitland

S Flint

C Scully

S J Crean

Affiliations

Soon will be listed here.

Abstract

To investigate the role of herpes viruses in Sjogren's syndrome, minor (labial) salivary gland tissues from Sjogren's syndrome and from non-specific sialadenitis were examined for Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) DNA by the polymerase chain reaction. Almost half of all salivary glands studied contained EBV and/or HCMV. There was, however, no significant difference between the detection of EBV or HCMV in salivary glands from patients with Sjogren's syndrome or non-specific sialadenitis. The findings are consistent with the persistence of EBV and HCMV in minor salivary glands following primary infection, but do not indicate a direct role for either virus in the aetiology of Sjogren's syndrome, and do not exclude reactivation of the viruses in this disease.

Citing Articles

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