Malignant Lymphoma and Exposure to Chemicals, Especially Organic Solvents, Chlorophenols and Phenoxy Acids: a Case-control Study

Overview

Journal Br J Cancer

Specialty Oncology

Date 1981 Feb 1

PMID 7470379

Citations 86

Authors

L Hardell

M Eriksson

P Lenner

E Lundgren

Affiliations

Soon will be listed here.

Abstract

A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chlorophenols, and organic solvents may be a causative factor in malignant lymphoma. Combined exposure of these chemicals seemed to increase the risk. Exposure to various other agents was not obviously different in cases and in controls.

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References

Bjorkholm M, Holm G, Mellstedt H . Immunologic profile of patients with cured Hodgkin's disease. Scand J Haematol. 1977; 18(5):361-8. DOI: 10.1111/j.1600-0609.1977.tb02090.x. View

Vos J, Moore J, Zinkl J . Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ Health Perspect. 1973; 5:149-62. PMC: 1474978. DOI: 10.1289/ehp.7305149. View

Hoover R, Fraumeni Jr J . Risk of cancer in renal-transplant recipients. Lancet. 1973; 2(7820):55-7. DOI: 10.1016/s0140-6736(73)93256-x. View

Greim H, BONSE G, Radwan Z, Reichert D, Henschler D . Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation. Biochem Pharmacol. 1975; 24(21):2013-7. DOI: 10.1016/0006-2952(75)90396-2. View

Miettinen O . Estimability and estimation in case-referent studies. Am J Epidemiol. 1976; 103(2):226-35. DOI: 10.1093/oxfordjournals.aje.a112220. View

VIGLIANI E, Forni A . Benzene and leukemia. Environ Res. 1976; 11(1):122-7. DOI: 10.1016/0013-9351(76)90115-8. View

Vainio H, Paakkonen R, Ronnholm K, RAUNIO V, Pelkonen O . A study on the mutagenic activity of styrene and styrene oxide. Scand J Work Environ Health. 1976; 2(3):147-51. DOI: 10.5271/sjweh.2813. View

Grufferman S, Duong T, Cole P . Occupation and Hodgkin's disease. J Natl Cancer Inst. 1976; 57(5):1193-5. DOI: 10.1093/jnci/57.5.1193. View

Gutensohn N, Cole P . Epidemiology of hodgkin's disease in the young. Int J Cancer. 1977; 19(5):595-604. DOI: 10.1002/ijc.2910190502. View

10.

Infante P, Rinsky R, Wagoner J, Young R . Leukaemia in benzene workers. Lancet. 1977; 2(8028):76-8. DOI: 10.1016/s0140-6736(77)90074-5. View

11.

Hardell L . Malignant lymphoma of histiocytic type and exposure to phenoxyacetic acids or chlorophenols. Lancet. 1979; 1(8106):55-6. DOI: 10.1016/s0140-6736(79)90509-9. View

12.

Seiler J . The genetic toxicology of phenoxy acids other than 2,4,5-T. Mutat Res. 1978; 55(3-4):197-226. DOI: 10.1016/0165-1110(78)90004-0. View

13.

Hardell L, Sandstrom A . Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br J Cancer. 1979; 39(6):711-7. PMC: 2009993. DOI: 10.1038/bjc.1979.125. View

14.

Seiler J . Phenoxyacids as inhibitors of testicular DNA synthesis in male mice. Bull Environ Contam Toxicol. 1979; 21(1-2):89-92. DOI: 10.1007/BF01685392. View

15.

Vianna N, POLAN A . Lymphomas and occupational benzene exposure. Lancet. 1979; 1(8131):1394-5. DOI: 10.1016/s0140-6736(79)92022-1. View

16.

Axelson O . The case-referent (case-control) study in occupational health epidemiology. Scand J Work Environ Health. 1979; 5(2):91-9. DOI: 10.5271/sjweh.2654. View

17.

Lenner P, Lundgren E, Damber L . Clinico-pathologic correlation in non-Hodgkin's lymphoma. I. Retrospective analysis using the Lukes and Collins classification. Acta Radiol Oncol Radiat Phys Biol. 1979; 18(3):177-91. DOI: 10.3109/02841867909128205. View

18.

Kinlen L, SHEIL A, Peto J, DOLL R . Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs. Br Med J. 1979; 2(6203):1461-6. PMC: 1597175. DOI: 10.1136/bmj.2.6203.1461. View

19.

Axelson O . A note on observational bias in case-referent studies in occupational health epidemiology. Scand J Work Environ Health. 1980; 6(1):80-2. DOI: 10.5271/sjweh.2630. View

20.

Olin G, Ahlbom A . The cancer mortality among Swedish chemists graduated during three decades. A comparison with the general population and with a cohort of architects. Environ Res. 1980; 22(1):154-61. DOI: 10.1016/0013-9351(80)90127-9. View