Neurochemical Effects on Rats of N-heptane Inhalation Exposure

Overview

Journal Arch Environ Contam Toxicol

Specialty Environmental Health

Date 1980 Jan 1

PMID 7469483

Citations 2

Authors

H Savolainen

P Pfaffli

Affiliations

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Abstract

Inhalation exposure of male rats at three dose levels (4.2, 21, 62 mol/L) to n-heptane vapor caused a dose-dependent brain and body solvent burden, which increased during two weeks of exposure. Initial neurochemical effects included reduced RNA concentration and increased NADPH-diaphorase in brain at the lowest dose. Increased proteolysis was detected in the cerebral samples in the second week at all doses, and the NADPH-diaphorase returned to the control range. Brain RNA content tended to be larger than in the controls. All biochemical effects were abolished after two weeks of withdrawal from the two-week exposure, with the exception of reduced glutathione at the lowest dose. None of the rats presented clinical signs of neuropathy, which indicates that heptane and its metabolites do not share the specific neurotoxicity of hexane and its metabolites.

Citing Articles

Updating federal standards for toxicants: n-Hexane as the model.

Babich H, Davis D, Adler R Environ Monit Assess. 2013; 2(3):287-99.

PMID: 24264298 DOI: 10.1007/BF00394458.

Identification of the n-heptane metabolites in rat and human urine.

Perbellini L, Brugnone F, Cocheo V, De Rosa E, Bartolucci G Arch Toxicol. 1986; 58(4):229-34.

PMID: 3718225 DOI: 10.1007/BF00297111.

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