Interaction of Age and Sex in Sympathetic Axon Ingrowth into the Hippocampus Following Septal Afferent Damage

Overview

Journal Anat Embryol (Berl)

Specialties Anatomy & Histology
Reproductive Medicine

Date 1980 Jan 1

PMID 7469040

Citations 2

Authors

T A Milner

R Loy

Affiliations

Soon will be listed here.

Abstract

Damage to the medial septal nucleus or to the fimbria/fornix in the adult rat elicits sprouting of vascular sympathetic fibers into the deafferented regions of the hippocampal formation. The following study examines the effects of developmental stage and sex on this sprouting phenomenon using both fluorescence histochemistry and high affinity uptake of noradrenaline. We find that (1) the sprouting, which is reduced in adult and juvenile males relative to females, is equivalent in the two sexes after transections at postnatal day 3, and (2) the period of maximum ingrowth is sexually regulated, occurring near postnatal day 3 in the male and postnatal day 13 in the female.

Citing Articles

Association of sympathetic axons in denervated hippocampus to intracerebral vasculature. I. Fluorescence histochemistry combining glyoxylic acid and pontamine sky blue.

McGinty J, Milner T, Loy R Anat Embryol (Berl). 1982; 164(1):95-100.

PMID: 7114493 DOI: 10.1007/BF00301882.

Septal deafferentation increases hippocampal adrenergic receptors: correlation with sympathetic axon sprouting.

Morrow A, Loy R, Creese I Proc Natl Acad Sci U S A. 1983; 80(21):6718-22.

PMID: 6314338 PMC: 391242. DOI: 10.1073/pnas.80.21.6718.

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