Gallstones and the Risk of Cancer

Overview

Journal Gut

Specialty Gastroenterology

Date 1980 Dec 1

PMID 7461469

Citations 12

Authors

A B Lowenfels

Affiliations

Soon will be listed here.

Abstract

For both males and females the age-standardised prevalence of asymptomatic gallstones found at necropsy in 15 countries correlated strongly with age-standardised mortality from cancers of the uterus, large bowel, and stomach. When deaths from cholecystitis were used as another measure of the frequency of gallstones similar positive correlations were observed across 28 countries. The results suggest that cholelithiasis and several common cancers share similar epidemiological and perhaps metabolic factors.

Citing Articles

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones.

Chen C, Lin C, Kao C Cancers (Basel). 2020; 12(3).

PMID: 32120816 PMC: 7139917. DOI: 10.3390/cancers12030544.

Gallbladder Polyps Are Associated with Proximal Colon Polyps.

Lee K, Jeng W, Hsu C, Kuo C, Su M, Chiu C Gastroenterol Res Pract. 2019; 2019:9832482.

PMID: 31611916 PMC: 6757279. DOI: 10.1155/2019/9832482.

Study on the Relation between Colorectal Cancer and Gall Bladder Disease.

Gosavi S, Mishra R, Kumar V J Clin Diagn Res. 2017; 11(3):OC25-OC27.

PMID: 28511430 PMC: 5427356. DOI: 10.7860/JCDR/2017/22954.9485.

Association between gallbladder stone disease and prostate cancer: A nationwide population-based study.

Chen C, Lin C, Kao C Oncotarget. 2016; 7(39):64380-64389.

PMID: 27147576 PMC: 5325450. DOI: 10.18632/oncotarget.9062.

Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study.

Chen Y, Yeh J, Lin C, Peng C, Sung F, Hwang I J Gastroenterol. 2013; 49(5):923-31.

PMID: 23807230 DOI: 10.1007/s00535-013-0846-6.

References

SIEVERS M . Unusual comparative frequency of gastric carcinoma, pernicious anemia, and peptic ulcer in southwestern American Indians. Gastroenterology. 1973; 65(6):867-76. View

Kalos A, Delidou A, Kordosis T, Archimandritis A, Gaganis A, ANGELOPOULOS B . The incidence of gallstones in Greece; an autopsy study. Acta Hepatogastroenterol (Stuttg). 1977; 24(1):20-3. View

TORVIK A, HOIVIK B . Gallstones in an autopsy series. Incidence, complications, and correlations with carcinoma of the gallbladder. Acta Chir Scand. 1960; 120:168-74. View

Marinovic I, Guerra C, Larach G . [Incidence of cholelithiasis in autopsy material and analysis of the composition of calculi]. Rev Med Chil. 1972; 100(11):1320-7. View

Rose G, Blackburn H, Keys A, Taylor H, Kannel W, Paul O . Colon cancer and blood-cholesterol. Lancet. 1974; 1(7850):181-3. DOI: 10.1016/s0140-6736(74)92492-1. View

Mack T, Pike M, Henderson B, Pfeffer R, Gerkins V, Arthur M . Estrogens and endometrial cancer in a retirement community. N Engl J Med. 1976; 294(23):1262-7. DOI: 10.1056/NEJM197606032942304. View

RODEWALD H . [Pathology of the gallbladder. II. Frequency of gallstones]. Zentralbl Allg Pathol. 1957; 96(5-6):300-2. View

ZAHOR A, Sternby N, Kagan A, Uemura K, VANECEK R, Vichert A . Frequency of cholelithiasis in Prague and Malmö. An autopsy study. Scand J Gastroenterol. 1974; 9(1):3-7. View

Doouss T, Castleden W . Gallstones and carcinoma of the large bowel. N Z Med J. 1973; 77(490):162-5. View

10.

Lieber M . The incidence of gallstones and their correlation with other diseases. Ann Surg. 1952; 135(3):394-405. PMC: 1802325. DOI: 10.1097/00000658-195203000-00011. View

11.

. Prevalence of gall stones in Dundee: a necropsy study. Br Med J. 1975; 4(5994):427-30. PMC: 1675416. DOI: 10.1136/bmj.4.5994.427. View

12.

Valdivieso V, Palma R, Nervi F, Covarrubias C, Severin C, ANTEZANA C . Secretion of biliary lipids in young Chilean women with cholesterol gallstones. Gut. 1979; 20(11):997-1000. PMC: 1412685. DOI: 10.1136/gut.20.11.997. View

13.

Capron J, Delamarre J, Canarelli J, Brousse N, Dupas J . [Does cholecystectomy predispose to colo-rectal cancer?]. Gastroenterol Clin Biol. 1978; 2(4):383-9. View

14.

Hoare A . Letter: Carcinoma of the colon and cholecystectomy. Lancet. 1974; 2(7893):1395-6. DOI: 10.1016/s0140-6736(74)92276-4. View

15.

NEWMAN H, NORTHUP J . The autopsy incidence of gallstones. Surg Gynecol Obstet. 1959; 109(1):1-13. View

16.

Burkitt D, Tunstall M . Gall-stones: geographical and chronological features. J Trop Med Hyg. 1975; 78(6):140-4. View

17.

Castleden W, Doouss T, Jennings K, Leighton M . Gallstones, carcinoma of the colon and diverticular disease. Clin Oncol. 1978; 4(2):139-44. View

18.

CLELAND J . Gall-stones in seven thousand post-mortem examinations. Med J Aust. 1953; 2(13):488-9. View

19.

Hogan J, Lonergan M, HOLLAND P . The incidence of cholelithiasis in an autopsy series. Ir Med J. 1977; 70(20):608-11. View

20.

Barker D, Gardner M, Power C, HUTT M . Prevalence of gall stones at necropsy in nine British towns: a collaborative study. Br Med J. 1979; 2(6202):1389-92. PMC: 1597054. DOI: 10.1136/bmj.2.6202.1389. View