Recent Pathogenic Aspects in Essential Hypertension and Hypertension Associated with Diabetes Mellitus

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1980 Oct 1

PMID 7453095

Citations 6

Authors

P Weidmann

Affiliations

Soon will be listed here.

Abstract

The sympathetic system, the body sodium-fluid volume state, the renin-angiotensin system, functional and structural characteristics of the heart and blood vessels, and some other components are important complementary factors in blood pressure regulation. A deviation from the normal equilibrium among these components, with a persisting non-physiologic increase in pressor factor(s) or in the basal vascular tone and/or cardiovascular reactivity to pressor factors, leads to hypertension. This review discusses recent observations and concepts regarding the pathogenesis of essential hypertension and hypertension associated with diabetes mellitus. It focuses on the roles of various pressor factors as well as cardiovascular pressor responsiveness in the genesis of high blood pressure and in the antihypertensive mechanism of diuretic treatment.

Citing Articles

The pathogenesis of hypertension in obese subjects.

Weidmann P, de Courten M, Boehlen L, Shaw S Drugs. 1993; 46 Suppl 2:197-208; discussion 208-9.

PMID: 7512475 DOI: 10.2165/00003495-199300462-00030.

Correction of altered noradrenaline reactivity in essential hypertension by indapamide.

Grimm M, Weidmann P, Meier A, Keusch G, Ziegler W, Gluck Z Br Heart J. 1981; 46(4):404-9.

PMID: 7295437 PMC: 482668. DOI: 10.1136/hrt.46.4.404.

Arachidonic acid metabolites, hypertension and arteriosclerosis.

Weber P, Siess W, Scherer B, Held E, WITZGALL H, Lorenz R Klin Wochenschr. 1982; 60(10):479-88.

PMID: 6954329 DOI: 10.1007/BF01756093.

Antihypertensive mechanism of the diuretic muzolimine in mild renal failure. Roles of sodium and cardiovascular norepinephrine responsiveness.

Schiffl H, Weidmann P, Cottier C, SEILER A, ZIEGLER W Eur J Clin Pharmacol. 1982; 23(3):215-20.

PMID: 6756933 DOI: 10.1007/BF00547556.

Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function.

Knauf H, Liebig R, Schollmeyer P, Rosenthal J, Kolle E, Mutschler E Eur J Clin Pharmacol. 1984; 26(6):687-93.

PMID: 6386484 DOI: 10.1007/BF00541926.

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