The Effects of Cholecystokinin-pancreozymin (CCK-PZ) on the Movement of the Terminal Part of the Bile Duct in Rabbits and Humans

The movement of the terminal part of the bile duct in rabbits and humans were recorded by a pressure sensor, and the effect of CCK-PZ to the movement were examined. The movement of the terminal part of the rabbit bile duct was accelerated immediately after giving a large dose of CCK-PZ intravenously but this was suppressed by slow intravenous administration of a small dose of CCK-PZ. The effect of CCK-PZ was inhibited by secretin but it was not affected by pretreatment with vagotomy. In patients, the effect of CCK-PZ on the movement of the terminal part of the bile duct was measured with a pressure sensor using a duodenofiberscope. Following 1 to 2 u/kg of CCK-PZ intravenously, this movement was immediately reduced and the regular wave pattern usually disappeared. This continued for several minutes but later this was accelerated gradually and then excretion of bile was seen from the papillary orifice. These results indicate that the intravenous administration of CCK-PZ increased activity of the papillary movement to promote the smooth excretion of bile in rabbits and humans.