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Demonstration of a Heritable Fragile Site in Human Chromosome 16 with Distamycin A

Overview
Publisher Karger
Specialty Genetics
Date 1980 Jan 1
PMID 7449440
Citations 21
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Abstract

Fragile sites are induced in chromosome 16 (band q22) of lymphocytes from some individuals, when the lymphocyte cultures are treated with the oligopeptide antibiotic distamycin A. These induced fragile sites are inherited in a Mendelian fashion; there are interfamilial differences in their appearance. The interactions between distamycin A and chromosomal DNA and the possible composition of the DNA at the induced fragile sites are discussed.

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