Evolutionary Constraints in the Mechanism of Flavin Catalysis

Overview

Journal Naturwissenschaften

Specialty Science

Date 1980 Nov 1

PMID 7442813

Citations 1

Authors

C M Visser

Affiliations

Soon will be listed here.

Abstract

Analysis of the possible evolution of flavin catalysis in succinate dehydrogenase suggests as the ultimate state an active site that bears one or more acid functions and uses the enediol form of the substrate rather than the carbanion as a nucleophile. In the case of flavoenzyme catalyzed oxidation of fatty acylCoA, alpha-amino acids and alpha-hydroxy acids evolution to a similar mechanism seems to be blocked.

Citing Articles

Evolutionary roots of catalysis by nicotinamide and flavins in C-H oxidoreductases and in photosynthesis.

Visser C Orig Life. 1982; 12(2):165-79.

PMID: 6216447 DOI: 10.1007/BF00927143.

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