Effects of Treatment with Muramyl Dipeptide and Certain of Its Analogs on Resistance to Listeria Monocytogenes in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1980 Nov 1

PMID 7439991

Citations 9

Authors

R C Humphres

P R Henika

R W FERRARESI

J L Krahenbuhl

Affiliations

Soon will be listed here.

Abstract

Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (MDP) afforded any resistance to infection with Listeria monocytogenes. Regardless of the timing, dose, or route of administration, there was no evidence that treatment with either MDP or two of its analogs (des-MDP or MDP-D-D) induced any resistance to listeria infection in BALB/c, CBA/J, or C57BL/6J mice. In contrast, pretreatment with MDP induced marked protection to infection with Streptococcus pneumoniae (type III).

Citing Articles

Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice.

Matthews T Infect Immun. 1981; 34(3):676-83.

PMID: 7333666 PMC: 350924. DOI: 10.1128/iai.34.3.676-683.1981.

Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.

Krahenbuhl J, Sharma S, FERRARESI R, Remington J Infect Immun. 1981; 31(2):716-22.

PMID: 7216470 PMC: 351369. DOI: 10.1128/iai.31.2.716-722.1981.

Correlation between in vivo anti-Pseudomonas and anti-Candida activities and clearance of carbon by the reticuloendothelial system for various muramyl dipeptide analogs, using normal and immunosuppressed mice.

Waters R, Matthews T Infect Immun. 1982; 35(1):105-10.

PMID: 7054119 PMC: 351002. DOI: 10.1128/iai.35.1.105-110.1982.

Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections.

Osada Y, Mitsuyama M, Une T, Matsumoto K, Otani T, Satoh M Infect Immun. 1982; 37(1):292-300.

PMID: 6809630 PMC: 347526. DOI: 10.1128/iai.37.1.292-300.1982.

Effects of muramyl dipeptide on superoxide anion release and on anti-microbial activity of human macrophages.

Wilson C, Bohnsack J, WEAVER W Clin Exp Immunol. 1982; 49(2):371-6.

PMID: 6290115 PMC: 1536489.

References

Mackaness G . The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969; 129(5):973-92. PMC: 2138649. DOI: 10.1084/jem.129.5.973. View

NORTH R . Cellular kinetics associated with the development of acquired cellular resistance. J Exp Med. 1969; 130(2):299-314. PMC: 2138681. DOI: 10.1084/jem.130.2.299. View

Ellouz F, Adam A, Ciorbaru R, Lederer E . Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1974; 59(4):1317-25. DOI: 10.1016/0006-291x(74)90458-6. View

Merser C, Sinay P, Adam A . Total synthesis and adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1975; 66(4):1316-22. DOI: 10.1016/0006-291x(75)90503-3. View

Juy D, CHEDID L . Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants. Proc Natl Acad Sci U S A. 1975; 72(10):4105-9. PMC: 433147. DOI: 10.1073/pnas.72.10.4105. View

Audibert F, CHEDID L, Lefrancier P, CHOAY J . Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components. Cell Immunol. 1976; 21(2):243-9. DOI: 10.1016/0008-8749(76)90053-8. View

Azuma I, Sugimura K, Taniyama T, Yamawaki M, Yamamura Y . Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds. Infect Immun. 1976; 14(1):18-27. PMC: 420838. DOI: 10.1128/iai.14.1.18-27.1976. View

CHEDID L, Audibert F, Lefrancier P, CHOAY J, Lederer E . Modulation of the immune response by a synthetic adjuvant and analogs. Proc Natl Acad Sci U S A. 1976; 73(7):2472-5. PMC: 430612. DOI: 10.1073/pnas.73.7.2472. View

Lowy I, Bona C, CHEDID L . Target cells for the activity of a synthetic adjuvant: muramyl dipeptide. Cell Immunol. 1977; 29(1):195-9. DOI: 10.1016/0008-8749(77)90288-x. View

10.

CHEDID L, Parant M, Parant F, Lefrancher P, CHOAY J, Lederer E . Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs. Proc Natl Acad Sci U S A. 1977; 74(5):2089-93. PMC: 431080. DOI: 10.1073/pnas.74.5.2089. View

11.

Specter S, Friedman H, CHEDID L . Dissociation between the adjuvant vs mitogenic activity of a synthetic muramyl dipeptide for murine splenocytes. Proc Soc Exp Biol Med. 1977; 155(3):349-52. DOI: 10.3181/00379727-155-39804. View

12.

Wing E, Gardner I, Ryning F, Remington J . Dissociation of effector functions in populations of activated macrophages. Nature. 1977; 268(5621):642-4. DOI: 10.1038/268642a0. View

13.

Damais C, Parant M, CHEDID L, Lefrancier P, CHOAY J . In vitro spleen cell responsiveness to various analogs of MDP (N-acetylmuramyl-L-alanyl-D-isoglutamine), a synthetic immunoadjuvant, in MDP high-responder mice. Cell Immunol. 1978; 35(1):173-9. DOI: 10.1016/0008-8749(78)90137-5. View

14.

Prunet J, Birrien J, PANIJEL J, Liacopoulos P . On the mechanism of early recovery of specifically depleted lymphoid cell populations by nonspecific activation of T cells. Cell Immunol. 1978; 37(1):151-61. DOI: 10.1016/0008-8749(78)90183-1. View

15.

Leclerc C, Lowy I, CHEDID L . Influence of MDP and of some analogous synthetic glycopeptides on the in vitro mouse spleen cell viability and immune response to sheep erythrocytes. Cell Immunol. 1978; 38(2):286-93. DOI: 10.1016/0008-8749(78)90059-x. View

16.

Parant M, Parant F, CHEDID L . Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. Proc Natl Acad Sci U S A. 1978; 75(7):3395-9. PMC: 392783. DOI: 10.1073/pnas.75.7.3395. View

17.

Karnovsky M, Lazdins J . Biochemical criteria for activated macrophages. J Immunol. 1978; 121(3):809-13. View

18.

Fevrier M, Birrien J, Leclerc C, CHEDID L, Liacopoulos P . The macrophage, target cell of the synthetic adjuvant muramyl dipeptide. Eur J Immunol. 1978; 8(8):558-62. DOI: 10.1002/eji.1830080804. View

19.

Leclerc C, Juy D, CHEDID L . Inhibitory and stimulatory effects of a synthetic glycopeptide (MDP) on the in vitro PFC response: factors affecting the response. Cell Immunol. 1979; 42(2):336-43. DOI: 10.1016/0008-8749(79)90199-0. View

20.

Wahl S, Wahl L, McCarthy J, CHEDID L, Mergenhagen S . Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide. J Immunol. 1979; 122(6):2226-31. View