Virion Nucleic Acid of Ebola Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1980 Nov 1

PMID 7431486

Citations 12

Authors

R L Regnery

K M Johnson

M P Kiley

Affiliations

Soon will be listed here.

Abstract

The virion nucleic acid of Ebola virus consists of a single-stranded RNA with a molecular weight of approximately 4.0 x 10(6). The virion RNA did not bind to oligodeoxythymidylic acid-cellulose under conditions known to bind RNAs rich in polyadenylic acid and was not infectious under conditions which yielded infectious RNA from Sindbis virus, suggesting that Ebola virus virion nucleic acid is a negative-stranded RNA.

Citing Articles

Latest Trends in Nucleic Acids' Engineering Techniques Applied to Precision Medicine.

Pereira G Methods Mol Biol. 2022; 2575:25-38.

PMID: 36301469 DOI: 10.1007/978-1-0716-2716-7_2.

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19.

Loh D, Reiter R Int J Mol Sci. 2022; 23(15).

PMID: 35897696 PMC: 9368024. DOI: 10.3390/ijms23158122.

Mechanisms of Immune Evasion by Ebola Virus.

Bhattacharyya S Adv Exp Med Biol. 2021; 1313:15-22.

PMID: 34661889 DOI: 10.1007/978-3-030-67452-6_2.

Viral Suppression of RIPK1-Mediated Signaling.

Udawatte D, Rothman A mBio. 2021; 12(4):e0172321.

PMID: 34372694 PMC: 8406217. DOI: 10.1128/mBio.01723-21.

Ebola Vaccine: How Far are we?.

Sharma R, Jangid K, Anuradha J Clin Diagn Res. 2017; 11(5):DE01-DE04.

PMID: 28658761 PMC: 5483663. DOI: 10.7860/JCDR/2017/22184.9863.

References

Bishop D, Claybrook J, Spiegelman S . Electrophoretic separation of viral nucleic acids on polyacrylamide gels. J Mol Biol. 1967; 26(3):373-87. DOI: 10.1016/0022-2836(67)90310-5. View

Bellamy A, Shapiro L, August J, Joklik W . Studies on reovirus RNA. I. Characterization of reovirus genome RNA. J Mol Biol. 1967; 29(1):1-17. DOI: 10.1016/0022-2836(67)90177-5. View

Kissling R, ROBINSON R, Murphy F, Whitfield S . Agent of disease contracted from green monkeys. Science. 1968; 160(3830):888-90. DOI: 10.1126/science.160.3830.888. View

BOWEN E, Simpson D, Bright W, ZLOTNIK I, Howard D . Vervet monkey disease: studies on some physical and chemical properties of the causative agent. Br J Exp Pathol. 1969; 50(4):400-7. PMC: 2072109. View

Aviv H, Leder P . Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A. 1972; 69(6):1408-12. PMC: 426713. DOI: 10.1073/pnas.69.6.1408. View

Eaton B, Donaghue T, Faulkner P . Presence of poly (A) in the polyribosome-associated RNA of Sindbis-infected BHK cells. Nat New Biol. 1972; 238(82):109-11. DOI: 10.1038/newbio238109a0. View

Weissmann C, Billeter M, Goodman H, Hindley J, Weber H . Structure and function of phage RNA. Annu Rev Biochem. 1973; 42:303-28. DOI: 10.1146/annurev.bi.42.070173.001511. View

Repik P, Bishop D . Determination of the molecular weight of animal RNA viral genomes by nuclease digestions. I. Vesicular stomatitis virus and its defective T particle. J Virol. 1973; 12(5):969-83. PMC: 356726. DOI: 10.1128/JVI.12.5.969-983.1973. View

Semancik J . Detection of polyadenylic acid sequences in plant pathogenic RNAs. Virology. 1974; 62(1):288-91. DOI: 10.1016/0042-6822(74)90325-0. View

10.

NEWMAN J, Brown F . Absence of poly (A) from the infective RNA of Nodamura virus. J Gen Virol. 1976; 30(1):137-40. DOI: 10.1099/0022-1317-30-1-137. View

11.

Obijeski J, Bishop D, Murphy F, Palmer E . Structural proteins of La Crosse virus. J Virol. 1976; 19(3):985-97. PMC: 354939. DOI: 10.1128/JVI.19.3.985-997.1976. View

12.

Johnson K, Lange J, WEBB P, Murphy F . Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire. Lancet. 1977; 1(8011):569-71. DOI: 10.1016/s0140-6736(77)92000-1. View

13.

BOWEN E, Lloyd G, Harris W, Platt G, Baskerville A, Vella E . Viral haemorrhagic fever in southern Sudan and northern Zaire. Preliminary studies on the aetiological agent. Lancet. 1977; 1(8011):571-3. DOI: 10.1016/s0140-6736(77)92001-3. View

14.

Pattyn S, van der Groen G, Jacob W, Piot P, Courteille G . Isolation of Marburg-like virus from a case of haemorrhagic fever in Zaire. Lancet. 1977; 1(8011):573-4. DOI: 10.1016/s0140-6736(77)92002-5. View

15.

McMaster G, Carmichael G . Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc Natl Acad Sci U S A. 1977; 74(11):4835-8. PMC: 432050. DOI: 10.1073/pnas.74.11.4835. View

16.

WENGLER G, Gross H . Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses. Virology. 1978; 89(2):423-37. DOI: 10.1016/0042-6822(78)90185-x. View

17.

Mandel B . THE EXTRACTION OF RIBONUCLEIC ACID FROM POLIOVIRUS BY TREATMENT WITH SODIUM DODECYL SULFATE. Virology. 1964; 22:360-7. DOI: 10.1016/0042-6822(64)90026-1. View