New Phenotypic Marker for Lipopolysaccharide Responsiveness

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1980 Sep 1

PMID 7429635

Authors

S V Gollapudi

S H Gregory

M Kern

Affiliations

Soon will be listed here.

Abstract

Lipopolysaccharide-enhanced secretion of non-immunoglobulin proteins by bone marrow cells derived from responder, nonresponder, and low-responder mouse strains did not precisely correlate with the lipopolysaccharide responsiveness assessment based on the mitogenic reactivity of splenocytes. These findings suggest that enhancement of secretion of non-immunoglobulin protein may be useful for further characterization of lipopolysaccharide responsiveness.

References

Watson J, Largen M, McAdam K . Genetic control of endotoxic responses in mice. J Exp Med. 1978; 147(1):39-49. PMC: 2184109. DOI: 10.1084/jem.147.1.39. View

Zimmerman D, Okumura K, Rabkin C, Kern M . Differentiation of lymphoid cells: the use of specific antisera to characterize the cells required for the induction of immunoglobulin M production in vitro. J Immunol. 1974; 113(6):1891-6. View

Buckingham R, Castor C . The effect of bacterial products on synovial fibroblast function: hypermetabolic changes induced by endotoxin. J Clin Invest. 1972; 51(5):1186-94. PMC: 292249. DOI: 10.1172/JCI106912. View

SCHER I, Steinberg A, Berning A, Paul W . X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med. 1975; 142(3):637-50. PMC: 2189918. DOI: 10.1084/jem.142.3.637. View

Zimmerman D, Kern M . Differentiation of lymphoid cells: effect of serum and other mitogenic agents on the selective induction of immunoglobulin M secreting lymph node cells in tissue culture. J Immunol. 1973; 111(5):1326-33. View

Bog-Hansen T, Back U . Lipoprotein changes induced by bacterial lipopolysaccharides in 'non-responder' C3H/HeJ mice. FEBS Lett. 1979; 104(2):441-5. DOI: 10.1016/0014-5793(79)80870-4. View

Gollapudi S, Kern M . Lipid A induces cells, uniquely present in bone marrow, to secrete proteins other than immunoglobulins. Eur J Biochem. 1980; 108(1):233-7. DOI: 10.1111/j.1432-1033.1980.tb04716.x. View

Watson J, Kelly K, Largen M, Taylor B . The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J Immunol. 1978; 120(2):422-4. View

Moore R, Goodrum K, BERRY L . Mediation of an endotoxic effect by macrophages. J Reticuloendothel Soc. 1976; 19(3):187-97. View

10.

Haas G, Johnson A, Nowotny A . Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides. J Exp Med. 1978; 148(4):1081-6. PMC: 2185012. DOI: 10.1084/jem.148.4.1081. View

11.

Zimmerman D, Kern M . Differentiation of lymphoid cells: the in vitro emergence of immunoglobulin M-secreting cells. J Immunol. 1973; 111(3):761-9. View

12.

Vogel S, Hansen C, Rosenstreich D . Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol. 1979; 122(2):619-22. View

13.

Coutinho A, Forni L, Melchers F, Watanabe T . Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. Eur J Immunol. 1977; 7(5):325-8. DOI: 10.1002/eji.1830070517. View

14.

SULTZER B, Goodman G . Endotoxin protein: a B-cell mitogen and polyclonal activator of C3H/HeJ lymphocytes. J Exp Med. 1976; 144(3):821-7. PMC: 2190414. DOI: 10.1084/jem.144.3.821. View

15.

Morrison D, Betz S, Jacobs D . Isolation of a lipid A bound polypeptide responsible for "LPS-initiated" mitogenesis of C3H/HeJ spleen cells. J Exp Med. 1976; 144(3):840-6. PMC: 2190404. DOI: 10.1084/jem.144.3.840. View

16.

SCHER I, Ahmed A, Strong D, Steinberg A, Paul W . X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med. 1975; 141(4):788-803. PMC: 2189753. View

17.

Andersson J, Moller G, Sjoberg O . Selective induction of DNA synthesis in T and B lymphocytes. Cell Immunol. 1972; 4(4):381-93. DOI: 10.1016/0008-8749(72)90040-8. View

18.

McAdam K, Ryan J . C57BL/10/CR mice: nonresponders to activation by the lipid a moiety of bacterial lipopolysaccharide. J Immunol. 1978; 120(1):249-53. View

19.

Swenson R, Kern M . THE SYNTHESIS AND SECRETION OF gamma-GLOBULINS BY LYMPH NODE CELLS, I. THE MICROSOMAL COMPARTMENTALIZATION OF gamma-GLOBULINS. Proc Natl Acad Sci U S A. 1967; 57(2):417-22. PMC: 335522. DOI: 10.1073/pnas.57.2.417. View

20.

Skidmore B, Chiller J, Morrison D, Weigle W . Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol. 1975; 114(2 pt 2):770-5. View