Age-related Changes in Cell Localization and Proliferation in Lymph Nodes and Spleen After Antigenic Stimulation

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1980 Aug 1

PMID 7429546

Authors

J D Ansell

C M McDougall

H S Micklem

C J Inchley

Affiliations

Soon will be listed here.

Abstract

Antigen-dependent localization of 51Cr-labelled lymphocytes, and the subsequent uptake of IUdR into lymphoid organs has been studied as a function of age. Measures of cell localization indicated that while old age can alter the patterns of entry of lymphocytes into lymph nodes and spleen, these changes are variable and probably not sufficient alone to explain decreased primary antibody responses in old animals. Proliferation of cells, however, was consistently affected in both organs and this phenomenon is discussed in terms of abnormal T-cell function.

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