Article: Simultaneous cancer of the pancreas occurring in husband and wife

The simultaneous occurrence of cancer of the pancreas in husband and wife is reported. Both patients shared two dietary idiosyncrasies--namely, (1) the ingestion of copious amounts of margarine in which they cooked all their food and (2) the addition of 'coffee syrup', a liquid concentrate of coffee, to their ground coffee before percolation. The possible role of the latter in the aetiology of pancreatic cancer is discussed.

Citing Articles

Simultaneous presentation of pancreatic cancer in a genetically unrelated couple.

Yellu M, Olowokure O BMJ Case Rep. 2015; 2015.

PMID: 26581697 PMC: 4654141. DOI: 10.1136/bcr-2014-207760.

Extrahepatic biliary tract carcinoma occurring simultaneously in a married couple.

Kennedy S, Gillan J, OBEIRN S, McCarthy C, Connolly C Ir J Med Sci. 1986; 155(6):204-5.

PMID: 3733402 DOI: 10.1007/BF02939844.

Cancer of the pancreas in two brothers and one sister.

Ghadirian P, Simard A, Baillargeon J Int J Pancreatol. 1987; 2(5-6):383-91.

PMID: 3693982 DOI: 10.1007/BF02788437.

Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada.

Ghadirian P, Boyle P, Simard A, Baillargeon J, Maisonneuve P, Perret C Int J Pancreatol. 1991; 10(3-4):183-96.

PMID: 1787333 DOI: 10.1007/BF02924156.

References

1.

Wynder E, Reddy B, McCoy G, WEISBURGER J, Williams G . Diet and gastrointestinal cancer. Clin Gastroenterol. 1976; 5(3):463-82. View

2.

Levin D, Connelly R . Cancer of the pancreas. Available epidemiologic information and its implications. Cancer. 1973; 31(5):1231-6. DOI: 10.1002/1097-0142(197305)31:5<1231::aid-cncr2820310529>3.0.co;2-c. View

3.

Armstrong B, Garrod A, DOLL R . A retrospective study of renal cancer with special reference to coffee and animal protein consumption. Br J Cancer. 1976; 33(2):127-36. PMC: 2024935. DOI: 10.1038/bjc.1976.17. View

4.

Wynder E, Mabuchi K, Maruchi N, Fortner J . Epidemiology of cancer of the pancreas. J Natl Cancer Inst. 1973; 50(3):645-67. DOI: 10.1093/jnci/50.3.645. View

5.

McCarthy C, ESPINER H . Carcinoma of bile ducts in husband and wife. Gut. 1969; 10(2):94-7. PMC: 1552796. DOI: 10.1136/gut.10.2.94. View

6.

Reimer R, Fraumeni Jr J, Ozols R, Bender R . Pancreatic cancer in father and son. Lancet. 1977; 1(8017):911. DOI: 10.1016/s0140-6736(77)91244-2. View

7.

Challis B, Bartlett C . Possible cocarcinogenic effects of coffee constituents. Nature. 1975; 254(5500):532-3. DOI: 10.1038/254532a0. View

8.

HAMMOND E . Trends in cancer death rates and cure rates. Ann Intern Med. 1959; 50(2):300-12. DOI: 10.7326/0003-4819-50-2-300. View

9.

Johnson J, Zintel H . PANCREATIC CALCIFICATION AND CANCER OF THE PANCREAS. Surg Gynecol Obstet. 1963; 117:585-8. View

10.

Li F, Fraumeni Jr J, Mantel N, Miller R . Cancer mortality among chemists. J Natl Cancer Inst. 1969; 43(5):1159-64. View

11.

Mainz D, WEBSTER 3rd P . Pancreatic carcinoma. A review of etiologic considerations. Am J Dig Dis. 1974; 19(5):459-64. DOI: 10.1007/BF01255609. View

12.

Simon D, Yen S, Cole P . Coffee drinking and cancer of the lower urinary tract. J Natl Cancer Inst. 1975; 54(3):587-91. View

13.

GREEN Jr R, BAGGENSTOSS A, SPRAGUE R . Diabetes mellitus in association with primary carcinoma of the pancreas. Diabetes. 1958; 7(4):308-11. DOI: 10.2337/diab.7.4.308. View

14.

Mori H, Hirono I . Effect of coffee on carcinogenicity of cycasin. Br J Cancer. 1977; 35(3):369-71. PMC: 2025277. DOI: 10.1038/bjc.1977.51. View

Simultaneous Cancer of the Pancreas Occurring in Husband and Wife