Transplacental Infection and Embryonic Death Following Maternal Exposure to Porcine Parvovirus Near the Time of Conception

Overview

Journal Arch Virol

Specialty Microbiology

Date 1980 Jan 1

PMID 7425850

Citations 9

Authors

W L Mengeling

P S Paul

T T Brown

Affiliations

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Abstract

Each of 20 gilts (principals) from a commercial swine herd free of antibody for porcine parvovirus (PPV) was exposed intranasally and orally to PPV at the onset of gestation. The gilts were killed and necropsied 22 +/- 1 days later to determine the effect of the virus on their embryos. An equal number of gilts (controls of the same status, from the same herd, and bred to the same boars, were treated similarly except for exposure to PPV. The following data were obtained at necropsy and from subsequent laboratory tests. Principals had 223 corpora lutea (8 to 16/gilt) and 203 embryos (6 to 16/litter). Porcine parvovirus-infected embryos (1 to 9/litter) were detected in 12 (60 per cent) of the 20 litters. Of the 203 embryos of principals, 169 were alive and 34 were dead and in various stages of decomposition and resorption. Both virus and viral antigen were detected in 7 of the live embryos (1, 1, 2, and 3 in 4 litters) and in 32 of the dead embryos. With 1 exception, infected live embryos were next to infected dead littermates in the uterus suggesting the beginning of intrauterine spread of the virus. Controls had 234 corpora lutea (9 to 15/gilt) and 217 embryos (9 to 14/litter). None of their embryos were infected with PPV and all but 3 were alive.

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References

Wrathall A, Mengeling W . Effect of transferring parvovirus-infected fertilized pig eggs into seronegative gilts. Br Vet J. 1979; 135(3):255-61. DOI: 10.1016/s0007-1935(17)32885-3. View

Hogg G, Lenghaus C, Forman A . Experimental porcine parvovirus infection of foetal pigs resulting in abortion, histological lesions and antibody formation. J Comp Pathol. 1977; 87(4):539-49. DOI: 10.1016/0021-9975(77)90060-3. View

Joo H, Johnson R . The effect on reproductive performance of porcine parvovirus infection in a susceptible pig herd. Vet Rec. 1977; 100(12):237-9. DOI: 10.1136/vr.100.12.237. View

Anderson L . Growth, protein content and distribution of early pig embryos. Anat Rec. 1978; 190(1):143-53. DOI: 10.1002/ar.1091900112. View

Mengeling W, Cutlip R . Pathogenesis of in utero infection: experimental infection of five-week-old porcine fetuses with porcine parvovirus. Am J Vet Res. 1975; 36(08):1173-7. View

Narita M, Inui S, Kawakami Y, Kitamura K, Maeda A . Histopathological changes of the brain in swine fetuses naturally infected with procine parvovirus. Natl Inst Anim Health Q (Tokyo). 1975; 15(1):24-8. View

Cutlip R, Mengeling W . Pathogenesis of in utero infection: experimental infection of eight- and ten-week-old porcine fetuses with porcine parvovirus. Am J Vet Res. 1975; 36(12):1751-4. View

Mengeling W, Cutlip R, Wilson R, Parks J, Marshall R . Fetal mummification associated with porcine parvovirus infection. J Am Vet Med Assoc. 1975; 166(10):993-5. View

Wrathall A, Mengeling W . Effect of porcine parvovirus on development of fertilized pig eggs in vitro. Br Vet J. 1979; 135(3):249-54. DOI: 10.1016/s0007-1935(17)32884-1. View

10.

Gillick J . An outbreak of swine foetal mummification associated with porcine parvovirus. Aust Vet J. 1977; 53(2):105-6. DOI: 10.1111/j.1751-0813.1977.tb14903.x. View

11.

Joo H, Johnson R . Observations on the pathogenesis of porcine parvovirus infection. Arch Virol. 1976; 51(1-2):123-9. DOI: 10.1007/BF01317841. View

12.

Cropper M, DUNNE H, Leman A, STARKEY A, Hoefling D . Prevalence of antibodies to porcine enteroviruses and porcine parvovirus in body fluids of fetal pigs from small vs large litters. J Am Vet Med Assoc. 1976; 168(3):233-5. View

13.

Lucas M, CARTWRIGHT S, Wrathall A . Genital infection of pigs with porcine parvovirus. J Comp Pathol. 1974; 84(3):347-50. DOI: 10.1016/0021-9975(74)90008-5. View

14.

Rodeffer H, Leman A, DUNNE H, Cropper M, Sprecher D . Reproductive failure in swine associated with maternal seroconversion for porcine parvovirus. J Am Vet Med Assoc. 1975; 166(10):991-2. View

15.

Mengeling W, Brown T, Paul P, Gutekunst D . Efficacy of an inactivated virus vaccine for prevention of porcine parvovirus-induced reproductive failure. Am J Vet Res. 1979; 40(2):204-7. View

16.

Mengeling W, Cutlip R . Reproductive disease experimentally induced by exposing pregnant gilts to porcine parvovirus. Am J Vet Res. 1976; 37(12):1393-400. View

17.

Mengeling W . Prenatal infection following maternal exposure to porcine parvovirus on either the seventh or fourteenth day of gestation. Can J Comp Med. 1979; 43(1):106-9. PMC: 1319949. View

18.

Forman A, Lenghaus C, Hogg G, HALE C . Association of a parvovirus with an outbreak of foetal death and mummification in pigs. Aust Vet J. 1977; 53(7):326-9. DOI: 10.1111/j.1751-0813.1977.tb00241.x. View

19.

Lenghaus C, Forman A, HALE C . Experimental infection of 35, 50 and 60 day old pig foetuses with porcine parvovirus. Aust Vet J. 1978; 54(9):418-22. DOI: 10.1111/j.1751-0813.1978.tb05565.x. View

20.

CARTWRIGHT S, Lucas M, HUCK R . A small haemaggultinating porcine DNA virus. II. Biological and serological studies. J Comp Pathol. 1971; 81(1):145-55. DOI: 10.1016/0021-9975(71)90067-3. View