Actinomycosis Complicating Crohn's Disease

A case of secondary infection of Crohn's disease by Actinomyces is reported. Clinically, Crohn's disease and actinomycosis may be difficult to differentiate. The distinguishing histopathological features of secondary actinomycosis include multiloculated abscesses, sulfur granules, typical organisms seen with Gram stain, and rarely, necrotizing granulomata. As actinomycosis may be cured by surgery and/or antibiotics, a careful search for Actinomyces including anaerobic culture is recommended in Crohn's disease with abscess formation.