Cigarette Smoke Affects Lipolytic Activity in Isolated Rat Lungs

Overview

Journal Lipids

Specialty Biochemistry

Date 1980 Jul 1

PMID 7412510

Authors

J Hartiala

J Viikari

E Hietanen

H Toivonen

P Uotila

Affiliations

Soon will be listed here.

Abstract

Isolated perfused rat lungs liberated fatty acids at a rate of 15 mumol/hr during perfusion of triglyceride-rich medium through the pulmonary vascular bed. About 80% of this activity seemed to result from lipoprotein lipase and 20% to hormone-sensitive lipase. Ventilation of the lungs with cigarette smoke instead of air during the perfusion reduced fatty acid liberation by 23%. Pre-exposure of rats to cigarette smoke for either 1 or 10 days did not cause significant changes in lung lipolytic activity compared to sham-exposed controls.

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