Skin Test and Lymphocyte Stimulation in Delayed Hypersensitivity Against Staphylococcus Aureus Antigens. Development of Hypersensitivity

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1980 Jan 1

PMID 7406538

Authors

H P Grundmann

H Weiss

H Trachsel

H STORCK

Affiliations

Soon will be listed here.

Abstract

The development of delayed hypersensitivity against staphylococcal antigens in guinea pigs was observed from day 3 to day 50 after sensitization with staphylococcal homogenate in Freund's incomplete (FIA) and Freund's complete adjuvant (FCA). Skin test reactivity, stimulation of lymph node lymphocytes, and peripheral blood lymphocytes and the titre of precipitating antibodies were followed during this period. Maximal skin test reactivity as well as maximal lymphocyte responsiveness occurred at day 21 after sensitization in FCA-sensitized guinea pigs. In FIA-sensitized animals highest skin reactivity was observed at day 14 and maximal lymphocyte stimulation 35 days after sensitization. Precipitating antibodies reached a plateau at day 20 in plasma of animals sensitized with FCA and at day 35 in FIA-sensitized animals.

References

Clark J, Altman G, Fromowitz F . Basophil hypersensitivity response in rabbits. Infect Immun. 1977; 15(1):305-12. PMC: 421363. DOI: 10.1128/iai.15.1.305-312.1977. View

STORCK H . Experimental studies on the question of the importance of microbes in eczema genesis. Dermatologica. 1948; 66(3-4):177-262. View

Kotani S, Watanabe Y, Shimono T, Kinoshita F, Narita T . Immunoadjuvant activities of peptidoglycan subunits from the cell walls of Staphyloccus aureus and Lactobacillus plantarum. Biken J. 1975; 18(2):93-103. View

Dvorak H . Cutaneous basophil hypersensitivity. J Allergy Clin Immunol. 1976; 58(1 PT. 2):229-40. DOI: 10.1016/0091-6749(76)90159-7. View

ROCKL H . [The microbial eczema]. Z Haut Geschlechtskr. 1967; 42(13):475-84. View

Easmon C, GLYNN A . Cell-mediated immune responses in Staphylococcus aureus infections in mice. Immunology. 1975; 29(1):75-85. PMC: 1445861. View

Kowalski J, BERMAN D . Immunobiological activity of cell wall antigens of Staphylococcus aureus. Infect Immun. 1971; 4(3):205-11. PMC: 416289. DOI: 10.1128/iai.4.3.205-211.1971. View

Taubler J, MUDD S . Staphylococcal delayed hypersensitivity in mice. II. In vitro demonstration and specificity of delayed hypersensitivity. J Immunol. 1968; 101(3):550-5. View

Welbourn E, CHAMPION R, Parish W . Hypersensitivity to bacteria in eczema. III. Arthus-like responses to bacterial antigens without specific antibody. Br J Dermatol. 1976; 95(4):379-87. DOI: 10.1111/j.1365-2133.1976.tb00839.x. View

10.

Taubler J . Staphylococcal delayed hypersensitivity in mice. I. Induction and in vivo demonstration of delayed hypersensitivity. J Immunol. 1968; 101(3):546-9. View

11.

SCHROEPL F, NUELLER E, ROECKL H . [Experimental studies on the pathogenesis of microbial eczema. I. Animal experiment studies]. Arch Klin Exp Dermatol. 1963; 215:523-50. View

12.

BOE J . Investigations on the importance of bacterial allergy for the development of cutaneous infections due to staphylococci. Acta Derm Venereol. 2010; 26:111-36. View

13.

ROCKL H . [Studies on clinical manifestations and pathogenesis of microbial eczema. IV. The bacterial flora of eczematous skin; epicutaneous flap tests with bacteria and broth culture filtrates]. Hautarzt. 1956; 7(3):113-8. View

14.

Meyer J, Grundmann H, Weiss H, Trachsel H . [Delayed hypersensitivity against staphylococcal antigens in guinea pigs (author's transl)]. Dermatologica. 1979; 159(5):383-5. View

15.

Heczko P, GROV A, OEDING P . In vivo reactions of staphylococcal antigens. 1. Hypersensitivity to protein A. Acta Pathol Microbiol Scand B Microbiol Immunol. 1973; 81(6):731-40. DOI: 10.1111/j.1699-0463.1973.tb02268.x. View

16.

Meyer J, Grundmann H, Weiss H . Induction of delayed-type hypersensitivity to staphylococcal antigens in guinea pigs. J Invest Dermatol. 1978; 71(2):122-5. DOI: 10.1111/1523-1747.ep12546488. View

17.

RAFFEL S, NEWEL J . The delayed hypersensitivity induced by antigen-antibody complexes. J Exp Med. 1958; 108(6):823-41. PMC: 2136921. DOI: 10.1084/jem.108.6.823. View

18.

Agarwal D . Subcutaneous staphylococcal infection in mice. I. The role of cotton-dust in enhancing infection. Br J Exp Pathol. 1967; 48(4):436-49. PMC: 2093788. View

19.

Meyer J, Trachsel H . Precipitating antibodies in sera of normal blood donors against some antigens related to type III allergy, detected by counterimmunoelectrophoresis. Allergol Immunopathol (Madr). 1979; 7(3):205-10. View

20.

Parish W, Welbourn E, CHAMPION R . Hypersensitivity to bacteria in eczema. IV. Cytotoxic effect of antibacterial antibody on skin cells acquiring bacterial antigens. Br J Dermatol. 1976; 95(5):493-506. DOI: 10.1111/j.1365-2133.1976.tb00859.x. View