Bilateral Visual Inputs to the Dorsal Cap of Inferior Olive: Differential Localization and Inhibitory Interactions

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1980 Jan 1

PMID 7398837

Citations 9

Authors

T Takeda

K Maekawa

Affiliations

Soon will be listed here.

Abstract

There are two pathways known to mediate optic signals to the rabbit flocculus through the dorsal cap of the inferior olive; one (I) projects from the contralateral and the other (II) from the ipsilateral eye, both to the contralateral flocculus. The present study on anesthetized rabbits revealed that the two pathways are relayed at different loci of the dorsal cap, I at its caudal and II its rostral half. The ventrolateral outgrowth of the inferior olive also projects to the flocculus, but a prominent field potential could not be produced by optic signals. The present study further demonstrated that transmission in pathway I accompanies an inhibitory action upon that in II. Since direct stimulation of these pathways at preolivary levels revealed similar inhibition, and since this was reflected in the depression of antidromic invasion of dorsal cap neurons, it is concluded that inhibition occurs postsynaptically in dorsal cap neurons. Inhibition is unidirectional, as activities in pathway II did not influence those in I.

Citing Articles

Distinct neural substrates of duration-based and beat-based auditory timing.

Teki S, Grube M, Kumar S, Griffiths T J Neurosci. 2011; 31(10):3805-12.

PMID: 21389235 PMC: 3074096. DOI: 10.1523/JNEUROSCI.5561-10.2011.

Activity of neurons in the beta nucleus of the inferior olive of the rabbit evoked by natural vestibular stimulation.

Barmack N, Fagerson M, Fredette B, Mugnaini E, Shojaku H Exp Brain Res. 1993; 94(2):203-15.

PMID: 7689485 DOI: 10.1007/BF00230288.

Projections of the medial terminal nucleus of the accessory optic system upon pretectal nuclei in the pigmented rat.

Blanks R, GIOLLI R, Pham S Exp Brain Res. 1982; 48(2):228-37.

PMID: 7173360 DOI: 10.1007/BF00237218.

Mutual inhibition between olivary cell groups projecting to different cerebellar microzones in the cat.

Andersson G Exp Brain Res. 1984; 54(2):293-303.

PMID: 6327349 DOI: 10.1007/BF00236230.

Olivary afferents from the pretectal nuclei in the cat.

WALBERG F, Nordby T, Hoffmann K, Hollander H Anat Embryol (Berl). 1981; 161(3):291-304.

PMID: 6320690 DOI: 10.1007/BF00301827.

References

WALBERG F, Kotchabhakdi N, Hoddevik G . The olivocerebellar projections to the flocculus and paraflocculus in the cat, compared to those in the rabbit. A study using horseradish peroxidase as a tracer. Brain Res. 1979; 161(3):389-98. DOI: 10.1016/0006-8993(79)90670-x. View

CRILL W . Unitary multiple-spiked responses in cat inferior olive nucleus. J Neurophysiol. 1970; 33(2):199-209. DOI: 10.1152/jn.1970.33.2.199. View

Armstrong B, Harvey R . Responses in the inferior olive to stimulation of the cerebellar and cerebral cortices in the cat. J Physiol. 1966; 187(3):553-74. PMC: 1395949. DOI: 10.1113/jphysiol.1966.sp008108. View

Hoddevik G, BRODAL A . The olivocerebellar projection studied with the method of retrograde axonal transport of horseradish peroxidase. V. The projections to the flocculonodular lobe and the paraflocculus in the rabbit. J Comp Neurol. 1977; 176(2):269-80. DOI: 10.1002/cne.901760208. View

Armstrong D . Functional significance of connections of the inferior olive. Physiol Rev. 1974; 54(2):358-417. DOI: 10.1152/physrev.1974.54.2.358. View

Alley K, Baker R, SIMPSON J . Afferents to the vestibulo-cerebellum and the origin of the visual climbing fibers in the rabbit. Brain Res. 1975; 98(3):582-9. DOI: 10.1016/0006-8993(75)90375-3. View

Ito M, Nisimaru N, Yamamoto M . Specific patterns of neuronal connexions involved in the control of the rabbit's vestibulo-ocular reflexes by the cerebellar flocculus. J Physiol. 1977; 265(3):833-54. PMC: 1307851. DOI: 10.1113/jphysiol.1977.sp011747. View

Ito M, Jastreboff P, Miyashita Y . Adaptive modification of the rabbit's horizontal vestibulo-ocular reflex during sustained vestibular and optokinetic stimulation. Exp Brain Res. 1979; 37(1):17-30. DOI: 10.1007/BF01474250. View

Andersson G, OSCARSSON O . Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp Brain Res. 1978; 32(4):565-79. DOI: 10.1007/BF00239553. View

10.

Yamamoto M . Topographical representation in rabbit cerebellar flocculus for various afferent inputs from the brainstem investigated by means of retrograde axonal transport of horseradish peroxidase. Neurosci Lett. 1979; 12(1):29-34. DOI: 10.1016/0304-3940(79)91475-7. View

11.

Mizuno N, Mochizuki K, Akimoto C, Matsushima R . Pretectal projections to the inferior olive in the rabbit. Exp Neurol. 1973; 39(3):498-506. DOI: 10.1016/0014-4886(73)90034-4. View

12.

Maekawa K, Takeda T . Electrophysiological identification of the climbing and mossy fiber pathways from the rabbit's retina to the contralateral cerebellar flocculus. Brain Res. 1976; 109(1):169-74. DOI: 10.1016/0006-8993(76)90388-7. View

13.

Robinson D . Adaptive gain control of vestibuloocular reflex by the cerebellum. J Neurophysiol. 1976; 39(5):954-69. DOI: 10.1152/jn.1976.39.5.954. View

14.

HELLON R . The marking of electrode tip positions in nervous tissue. J Physiol. 1971; 214 Suppl:12P. View

15.

Maekawa K, Takeda T . Origin of descending afferents to the rostral part of dorsal cap of inferior olive which transfers contralateral optic activities to the flocculus. A horseradish peroxidase study. Brain Res. 1979; 172(3):393-405. DOI: 10.1016/0006-8993(79)90574-2. View

16.

Kyojimaekawa , Toshiakitakeda , Maekawa K, Takeda T . Mossy fiber responses evoked in the cerebellar flocculus of rabbits by stimulation of the optic pathway. Brain Res. 1975; 98(3):590-5. DOI: 10.1016/0006-8993(75)90376-5. View

17.

Gonshor A, Jones G . Short-term adaptive changes in the human vestibulo-ocular reflex arc. J Physiol. 1976; 256(2):361-79. PMC: 1309312. DOI: 10.1113/jphysiol.1976.sp011329. View

18.

BRODAL A, WALBERG F, Hoddevik G . The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. J Comp Neurol. 1975; 164(4):449-69. DOI: 10.1002/cne.901640405. View

19.

Armstrong D, ECCLES J, Harvey R, Matthews P . Responses in the dorsal accessory olive of the cat to stimulation of hind limb afferents. J Physiol. 1968; 194(1):125-45. PMC: 1365678. DOI: 10.1113/jphysiol.1968.sp008398. View

20.

Groenewegen H, Voogd J . The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of cat cerebellum. J Comp Neurol. 1977; 174(3):417-88. DOI: 10.1002/cne.901740304. View