Is the HpO Phenomenon in Tropical Populations Really Genetic?

Overview

Journal Hum Hered

Specialty Genetics

Date 1980 Jan 1

PMID 7390508

Citations 6

Authors

A Rougemont

M QUILICI

J Delmont

J P Ardissone

Affiliations

Soon will be listed here.

Abstract

Long-term studies of 98 unselected adults from a rural African community in Mali where malaria is endemic showed that the haptoglobin level of the blood increased significantly after 1 year of continuous anti-malarial treatment. This seems to indicate that hypo- or anhaptoglobinaemia in populations like this may in a considerable number of cases have a non-genetic basis.

Citing Articles

Identification and Diagnosis of Complete Haptoglobin Gene Deletion, One of the Genes Responsible for Adverse Posttransfusion Reactions.

Soejima M, Koda Y Biomedicines. 2024; 12(4).

PMID: 38672145 PMC: 11048176. DOI: 10.3390/biomedicines12040790.

A review of haptoglobin typing methods for disease association study and preventing anaphylactic transfusion reaction.

Ko D, Chang H, Kim T, Song E, Park K, Song J Biomed Res Int. 2013; 2013:390630.

PMID: 23555085 PMC: 3600241. DOI: 10.1155/2013/390630.

Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment.

Hirayama F Br J Haematol. 2012; 160(4):434-44.

PMID: 23215650 PMC: 3594969. DOI: 10.1111/bjh.12150.

A novel I247T missense mutation in the haptoglobin 2 beta-chain decreases the expression of the protein and is associated with ahaptoglobinemia.

Teye K, Quaye I, Koda Y, Soejima M, Pang H, Tsuneoka M Hum Genet. 2004; 114(5):499-502.

PMID: 14999562 DOI: 10.1007/s00439-004-1098-6.

The haptoglobin-gene deletion responsible for anhaptoglobinemia.

Koda Y, Soejima M, Yoshioka N, Kimura H Am J Hum Genet. 1998; 62(2):245-52.

PMID: 9463309 PMC: 1376878. DOI: 10.1086/301701.