Toxicological Studies of Liver Cells by Microspectrofluorometry
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Abstract
The kinetics of xenobiotic biotransformation was measured in single, isolated, perifused liver cells with microspectrofluorometry using highly sensitive photodetection systems. A program of further applications to biochemical toxicological problems is presented.
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References
1.
Thurman R, Marazzo D, Jones L, Kauffman F
. The continuous kinetic determination of p-nitroanisole O-demethylation in hemoglobin-free perfused rat liver. J Pharmacol Exp Ther. 1977; 201(2):498-506.
View
2.
Schlessinger J, Koppel D, Axelrod D, Jacobson K, Webb W, Elson E
. Lateral transport on cell membranes: mobility of concanavalin A receptors on myoblasts. Proc Natl Acad Sci U S A. 1976; 73(7):2409-13.
PMC: 430587.
DOI: 10.1073/pnas.73.7.2409.
View
3.
Burke M, Mayer R
. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab Dispos. 1974; 2(6):583-8.
View
4.
Burke M, Hallman H
. Microfluorimetric analysis of the cytochrome P448 associated, ethoxyresorufin O-deethylase activities of individual isolated rat hepatocytes. Biochem Pharmacol. 1978; 27(11):1539-44.
DOI: 10.1016/0006-2952(78)90482-3.
View
5.
Cherry R
. Measurement of protein rotational diffusion in membranes by flash photolysis. Methods Enzymol. 1978; 54:47-61.
DOI: 10.1016/s0076-6879(78)54007-x.
View