Impairment of Phagocytosis by Heterophils from Chickens During Ochratoxicosis

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 1980 Mar 1

PMID 7387156

Citations 2

Authors

C F Chang

P B Hamilton

Affiliations

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Abstract

The effect of graded concentrations of dietary ochratoxin A (0, O.5, 1.0, 2.0, 4.0, and 8.0 microgram/g of diet) on the in vitro phagocytic, locomotory, and bactericidal capacities of heterophils from broiler chickens was investigated. Both the percentage and the mean phagocytic activities were decreased significantly (P less than 0.05) at 4.0 and 8.0 microgram/g. Both directed and undirected locomotion of heterophila was impaired significantly at the same concentrations. A crossover experiment revealed that the reduced percentage of phagocytosis was associated with the heterophil itself and not with a serum factor such as complement. Heterophila from birds that consumed 4.0 microgram/g were not impaired in ability to kill engulfed bacteria.

Citing Articles

Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks.

Khan S, Venancio E, Fernandes E, Hirooka E, Oba A, K M C Flaiban K Toxins (Basel). 2018; 10(8).

PMID: 30082604 PMC: 6115841. DOI: 10.3390/toxins10080316.

Effect of aflatoxins on rat peritoneal macrophages.

Cusumano V, Costa G, Seminara S Appl Environ Microbiol. 1990; 56(11):3482-4.

PMID: 2176448 PMC: 184993. DOI: 10.1128/aem.56.11.3482-3484.1990.

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