Cleft Palate in Domestic Animals: Epidemiologic Features

Overview

Journal Teratology

Date 1980 Feb 1

PMID 7385051

Citations 7

Authors

J J Mulvihill

C G Mulvihill

W A Priester

Affiliations

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Abstract

Among 331 animals with cleft palate in a veterinary clinic-hospital population, cats, mixed breed dogs and German Shepherd Dogs had low risk for cleft palate; high rates were seen in English Bulldogs, some small purebred dogs and Charolais cattle, where cleft palate occurred as part of a syndrome of multiple malformations. Many of the epidemiologic characteristics resemble features of cleft palate in humans and suggest animal breeds suitable for exploration as animal models for use by experimental teratologists, developmental biologists, and clinicians.

Citing Articles

Cleft Lip and Palate in Four Full-Sib Puppies from a Single Litter of Staffordshire Bull Terrier Dogs: An Anatomical and Genetic Study.

Ruszkowski J, Nowacka-Woszuk J, Nowak T, Rozynek J, Serwanska-Leja K, Gogulski M Animals (Basel). 2023; 13(17).

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Mutation of the MYH3 gene causes recessive cleft palate in Limousine cattle.

Vaiman A, Fritz S, Beauvallet C, Boussaha M, Grohs C, Daniel-Carlier N Genet Sel Evol. 2022; 54(1):71.

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Exceptional Changes in Skeletal Anatomy under Domestication: The Case of Brachycephaly.

Geiger M, Schoenebeck J, Schneider R, Schmidt M, Fischer M, Sanchez-Villagra M Integr Org Biol. 2021; 3(1):obab023.

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Incidence patterns of orofacial clefts in purebred dogs.

Roman N, Carney P, Fiani N, Peralta S PLoS One. 2019; 14(11):e0224574.

PMID: 31682628 PMC: 6827884. DOI: 10.1371/journal.pone.0224574.

Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds.

Mansour T, Lucot K, Konopelski S, Dickinson P, Sturges B, Vernau K PLoS Genet. 2018; 14(12):e1007850.

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