A Replication Model for Sister-chromatid Exchange

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1980 May 1

PMID 7383040

Citations 46

Authors

R B Painter

Affiliations

Soon will be listed here.

Abstract

A model for the production of sister-chromatid exchanges is presented, based on the idea that double-strand breaks are generated at junctions between a completely duplicated replicon cluster and a partially duplicated replicon cluster. Agents that induce absolute blocks to DNA fork displacement will cause this condition to persist longer than normal, whereas agents that inhibit initiation of whole clusters will rarely cause it at all. During the blunt-end repair of the double-strand breaks, sister-chromatod exchange would be initiated when daughter strands of a duplicated cluster recombine with the parental strands of the partially replicated cluster. When the latter finishes replication, sister-chromatid exchange would be completed.

Citing Articles

YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells.

Cui X, Zhang C, Fu C, Hu J, Li T, Li L Nucleic Acids Res. 2024; 52(13):7401-7413.

PMID: 38869071 PMC: 11260479. DOI: 10.1093/nar/gkae502.

The Relevance of G-Quadruplexes for DNA Repair.

Linke R, Limmer M, Juranek S, Heine A, Paeschke K Int J Mol Sci. 2021; 22(22).

PMID: 34830478 PMC: 8620898. DOI: 10.3390/ijms222212599.

Cytotoxicity and Mutagenicity of Narrowband UVB to Mammalian Cells.

Buglewicz D, Mussallem J, Haskins A, Su C, Maeda J, Kato T Genes (Basel). 2020; 11(6).

PMID: 32545288 PMC: 7349664. DOI: 10.3390/genes11060646.

Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA.

OHara R, Arsenault M, Esparza Gonzalez B, Patriquen A, Hartwig S Can J Kidney Health Dis. 2019; 6:2054358119871936.

PMID: 31523438 PMC: 6734617. DOI: 10.1177/2054358119871936.

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.

van Wietmarschen N, Merzouk S, Halsema N, Spierings D, Guryev V, Lansdorp P Nat Commun. 2018; 9(1):271.

PMID: 29348659 PMC: 5773480. DOI: 10.1038/s41467-017-02760-1.