Immune Mechanisms Against Canine Distemper. III. Role of Complement Lysis in the Immunity and Persistent Infection of Canine Distemper Virus

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1980 Feb 1

PMID 7380468

Citations 4

Authors

C K Ho

L A Babiuk

Affiliations

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Abstract

Antibody-mediated complement lysis of Vero cells and canine macrophages infected with canine distemper virus (CDV) was demonstratee in an in vitro 51Cr release assay. This cytolytic activity was found to be highly efficient and was optimal under conditions which favoured the capping of redistribution of surface viral antigens. A prozone was observed in the presence of high antibody concentration and could not be eliminated by repeated washings. By tagging antibody-coated target cells with 125I-labelled staphylococcus protein A, it was found that the extent of protein A binding was parallel to the degree of cytotoxicity suggesting that the mechanism of this prozone effect was similar to that of a precipitation test.

Citing Articles

Immunopathogenic and neurological mechanisms of canine distemper virus.

Carvalho O, Botelho C, Ferreira C, Scherer P, Soares-Martins J, Almeida M Adv Virol. 2012; 2012:163860.

PMID: 23193403 PMC: 3501799. DOI: 10.1155/2012/163860.

Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs. Sequential immunologic and morphologic findings.

Higgins R, Krakowka S, Metzler A, Koestner A Acta Neuropathol. 1982; 58(1):1-8.

PMID: 7136512 PMC: 7086558. DOI: 10.1007/BF00692691.

Studies on the intrathecal humoral immune response in canine distemper encephalitis.

Vandevelde M, Zurbriggen A, Steck A, Bichsel P J Neuroimmunol. 1986; 11(1):41-51.

PMID: 3944250 PMC: 7119885. DOI: 10.1016/0165-5728(86)90073-1.

Canine distemper virus clearance in chronic inflammatory demyelination.

Bollo E, Zurbriggen A, Vandevelde M, FANKHAUSER R Acta Neuropathol. 1986; 72(1):69-73.

PMID: 3825508 DOI: 10.1007/BF00687949.

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