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» Articles » PMID: 7379337

Studies on Monocytes in Inflammatory Bowel Disease: Factors Influencing Monocyte Lysosomal Enzyme Activity

Overview
Journal Clin Exp Immunol
Publisher Oxford University Press
Specialty Allergy & Immunology
Date 1980 Mar 1
PMID 7379337
Citations 3
Authors
A S Mee
L Nuttall
B J Potter
D P Jewell
Affiliations
Soon will be listed here.
Abstract

The effect of endotoxin and immune complexes on monocyte lysosomal enzyme activity has been studied in patients with Crohn's disease and ulcerative colitis. Immune complexes made at equivalence or in antigen excess caused a rapid fall in intracellular activity of the enzyme N'acetyl-beta-D-glucosaminidase which was significantly greater than that seen when cells were incubated with medium alone. Endotoxin had no effect on intracellular enzyme activity but there was a significant elevation of activity in the supernatants. Cells from patients with inflammatory bowel disease were no different to cells from healthy control subjects in their response to either endotoxin or immune complexes.

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A comparative study of lysosomal enzyme activity in monocytes and Kupffer cells isolated simultaneously in a rat model of liver injury.

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