Hyperthermia in Cancer Therapy

Overview

Journal West J Med

Specialty General Medicine

Date 1980 Mar 1

PMID 7376656

Citations 10

Authors

K H Luk

R M Hulse

T L Phillips

Affiliations

Soon will be listed here.

Abstract

Many malignant cell lines exhibit a therapeutic response to supernormal temperatures. Selective destruction of tumor cells has been observed following moderate hyperthermia (42 degrees to 43 degrees C) in vivo, and tumor eradication by heat has been achieved without normal tissue morbidity. Thermal cell killing appears to be independent of oxygen tension, and the sensitivity of S-phase cells to thermal damage is complementary to that for cellular radiation response. Hyperthermia is therefore a promising adjunct to radiotherapy. At the Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, San Francisco, the differential thermal sensitivity of malignant cells is being studied to achieve improved tumor control in patients refractory to more conventional treatments. Preliminary results of a two-year clinical trial indicated increased local objective responses when hyperthermia and radiation were used in combination.

Citing Articles

Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology.

Gupta R, Tomar R, Chakraverty S, Sharma D RSC Adv. 2022; 11(28):16942-16954.

PMID: 35479670 PMC: 9032483. DOI: 10.1039/d1ra02376d.

Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer.

Mishra M, Singh N, Ghatage P Cureus. 2021; 13(6):e15563.

PMID: 34277186 PMC: 8272440. DOI: 10.7759/cureus.15563.

Hairpin Oligonucleotide Can Functionalize Gold Nanorods for Application Delivering Cytotoxic Nucleotides and Curcumin: A Comprehensive Study in Combination with Near-Infrared Laser.

Das U, Bhuniya A, Roy A, Gmeiner W, Ghosh S ACS Omega. 2020; 5(44):28463-28474.

PMID: 33195896 PMC: 7658950. DOI: 10.1021/acsomega.0c02288.

Preparation and Evaluation of Doxorubicin-Loaded PLA-PEG-FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy.

Khaledian M, Nourbakhsh M, Saber R, Hashemzadeh H, Darvishi M Int J Nanomedicine. 2020; 15:6167-6182.

PMID: 32922000 PMC: 7450214. DOI: 10.2147/IJN.S261638.

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer.

Riggs M, Pandalai P, Kim J, Dietrich C Diagnostics (Basel). 2020; 10(1).

PMID: 31947647 PMC: 7168334. DOI: 10.3390/diagnostics10010043.

References

SUGAAR S, LeVEEN H . A histopathologic study on the effects of radiofrequency thermotherapy on malignant tumors of the lung. Cancer. 1979; 43(2):767-83. DOI: 10.1002/1097-0142(197902)43:2<767::aid-cncr2820430254>3.0.co;2-x. View

Dickson J, Shah D . The effects of hyperthermia (42 degrees C) on the biochemistry and growth of a malignant cell line. Eur J Cancer (1965). 1972; 8(5):561-71. DOI: 10.1016/0014-2964(72)90110-7. View

PETTIGREW R, Galt J, Ludgate C, Horn D, Smith A . Circulatory and biochemical effects of whole body hyperthermia. Br J Surg. 1974; 61(9):727-30. DOI: 10.1002/bjs.1800610914. View

Muckle D, Dickson J . The selective inhibitory effect of hyperthermia on the metabolism and growth of malignant cells. Br J Cancer. 1971; 25(4):771-8. PMC: 2008852. DOI: 10.1038/bjc.1971.91. View

Dickson J, ELLIS H . Stimulation of tumour cell dissemination by raised temperature (42 degrees C) in rats with transplanted Yoshida tumours. Nature. 1974; 248(446):354-8. DOI: 10.1038/248354a0. View

Alfieri A, Hahn E, Kim J . The relationship between the time of fractionated and single doses of radiation and hyperthermia on the sensitization of an in vivo mouse tumor. Cancer. 1975; 36(3):893-903. DOI: 10.1002/1097-0142(197509)36:3<893::aid-cncr2820360310>3.0.co;2-u. View

CRILE Jr G . Heat as an adjunct to the treatment of cancer; experimental studies. Cleve Clin Q. 1961; 28:75-89. DOI: 10.3949/ccjm.28.2.75. View

Dickson J, Oswald B . The sensitivity of a malignant cell line to hyperthermia (42 degrees C) at low intracellular pH. Br J Cancer. 1976; 34(3):262-71. PMC: 2025171. DOI: 10.1038/bjc.1976.161. View

Suit H . Hyperthermic effects on animal tissues. Radiology. 1977; 123(2):483-7. DOI: 10.1148/123.2.483. View

10.

PETTIGREW R, Galt J, Ludgate C, Smith A . Clinical effects of whole-body hyperthermia in adnanced malignancy. Br Med J. 1974; 4(5946):679-82. PMC: 1612852. DOI: 10.1136/bmj.4.5946.679. View

11.

Dales S . Effects of anaerobiosis on the rates of multiplication of mammalian cells cultured in vitro. Can J Biochem Physiol. 1960; 38:871-8. View

12.

Auersperg N . Differential heat sensitivity of cells in tissue culture. Nature. 1966; 209(5021):415-6. DOI: 10.1038/209415a0. View

13.

Gerner E, Connor W, BOONE M, Doss J, MAYER E, Miller R . The potential of localized heating as a adjunct to radiation therapy. Radiology. 1975; 116(02):433-9. DOI: 10.1148/116.2.433. View

14.

Dewey W, Thrall D, GILLETTE E . Hyperthermia and radiation--a selective thermal effect on chronically hypoxic tumor cells in vivo. Int J Radiat Oncol Biol Phys. 1977; 2(1-2):99-103. DOI: 10.1016/0360-3016(77)90013-x. View

15.

STRAUSS A, Appel M, SAPHIR O, RABINOVITZ A . Immunologic resistance to carcinoma produced by electrocoagulation. Surg Gynecol Obstet. 1965; 121(5):989-96. View

16.

Ben-Hur E, Elkind M, Bronk B . Thermally enhanced radioresponse of cultured Chinese hamster cells: inhibition of repair of sublethal damage and enhancement of lethal damage. Radiat Res. 1974; 58(1):38-51. View

17.

CHRISTIANSEN E, Kvamme E . Effects of thermal treatment on mitochondria of brain, liver and ascites cells. Acta Physiol Scand. 1969; 76(4):472-84. DOI: 10.1111/j.1748-1716.1969.tb04494.x. View

18.

Overgaard K, Overgaard J . Investigation on the possibility of a thermic tumour therapy. II. Action of combined heat-roentgen treatment on a transplanted mouse mammary carcinoma. Eur J Cancer (1965). 1972; 8(5):573-5. DOI: 10.1016/0014-2964(72)90111-9. View

19.

Overgaard K, Overgaard J . Hyperthermic tumour-cell devitalization in vivo. Acta Radiol Ther Phys Biol. 1977; 16(1):1-16. DOI: 10.3109/02841867709133928. View

20.

Dewey W, Hopwood L, Sapareto S, Gerweck L . Cellular responses to combinations of hyperthermia and radiation. Radiology. 1977; 123(2):463-74. DOI: 10.1148/123.2.463. View