Circulating Immune Complexes in Patients with Gram Negative Septic Shock

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 1980 Jan 1

PMID 7365108

Citations 1

Authors

C George

J Carlet

A Sobel

L Intrator

M Robin

C Sabatier

D Prevot

M Rapin

Affiliations

Soon will be listed here.

Abstract

In order to explain complement components abnormalities observed during septic shock, circulating immune complexes (C.I.C.) were searched for in sera from 34 patients with gram negative sepsis by two different methods: polyethylene glycol precipitation test based on physical properties of C.I.C. and C1q deviation test based on the property of radiolabelled C1q to react with C.I.C. Serum immunoglobulins (IgG, IgA, IgM) and complement components (C1q, C3, C4) levels were simultaneously determined. Seventeen patients with minimal haemodynamic abnormalities had normal or increased levels (except C4 at 62% of normal) and in eleven cases both tests for C.I.C. were simultaneously positive. Seventeen patients with severe septic shock had a decrease in IgG, IgM C1q, C3 and C4 and none had both tests for C.I.C. simultaneously positive (P less than 10(-4)). The disappearence of C.I.C. in patients with severe septic shock associated with evidence of complement activation suggests their involvement in the pathogenesis of septic shock in man.

Citing Articles

Immunological aspects to severe bacterial sepsis.

Clumeck N, George C Intensive Care Med. 1981; 7(3):109-14.

PMID: 7012215 DOI: 10.1007/BF01738612.

References

McCabe W . Serum complement levels in bacteremia due to gram-negative organisms. N Engl J Med. 1973; 288(1):21-3. DOI: 10.1056/NEJM197301042880105. View

Maclean L, Meakins J, Taguchi K, Duignan J, Dhillon K, Gordon J . Host resistance in sepsis and trauma. Ann Surg. 1975; 182(3):207-17. PMC: 1343926. DOI: 10.1097/00000658-197509000-00004. View

Robin M, Intrator L, Rapin M . Letter: Complement activation in septic shock. N Engl J Med. 1975; 293(24):1261-2. DOI: 10.1056/nejm197512112932416. View

Sobel A, Cooper N, Schreiber R . Activation of the classical complement pathway by nephritic factor bound to the alternative pathway C3/C5 convertase. J Immunol. 1979; 122(1):34-8. View

Dupuy C, DUPUY J . Complement studies in severe viral hepatitis of childhood. Pathol Biol (Paris). 1977; 25(8):553-8. View

Robin M, Intrator L, Andre C, LAGRUE G, Rapin M . [Complement anomalies and infection-related shock]. Nouv Presse Med. 1974; 3(14):883-4. View

George C, Robin M, Carlet J, Rapin M, Landais C, Sabatier C . [Cellular immunity skin testing and sepis in intensive care patients : relationship between results and mortality (author's transl)]. Nouv Presse Med. 1978; 7(29):2541-4. View

Fearon D, Ruddy S, Schur P, McCabe W . Activation of the properdin pathway of complement in patients with gram-negative bacteremia. N Engl J Med. 1975; 292(18):937-40. DOI: 10.1056/NEJM197505012921802. View

JACOB H . Granulocyte-complement interaction. A beneficial antimicrobial mechanism that can cause disease. Arch Intern Med. 1978; 138(3):461-3. DOI: 10.1001/archinte.138.3.461. View

10.

HERREMAN G, Godeau P, Cabane J, DIGEON M, Laver M, Bach J . [Immunologic study of subacute infectious endocarditis through the search for circulating immune complexes. Preliminary results apropos of 13 cases]. Nouv Presse Med. 1975; 4(32):2311-4. View

11.

McCabe W, Kreger B, Johns M . Type-specific and cross-reactive antibodies in gram-negative bacteremia. N Engl J Med. 1972; 287(6):261-7. DOI: 10.1056/NEJM197208102870601. View

12.

Regnier B, Rapin M, Gory G, Lemaire F, Teisseire B, Harari A . Haemodynamic effects of dopamine in septic shock. Intensive Care Med. 1977; 3(2):47-53. DOI: 10.1007/BF01683060. View

13.

Mancini G, Carbonara A, Heremans J . Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965; 2(3):235-54. DOI: 10.1016/0019-2791(65)90004-2. View

14.

Sobel A, Bokisch V, MULLER-EBERHARD H . C1q deviation test for the detection of immune complexes, aggregates of IgG, and bacterial products in human serum. J Exp Med. 1975; 142(1):139-50. PMC: 2189879. DOI: 10.1084/jem.142.1.139. View

15.

Bayer A, Theofilopoulos A, Tillman D, Dixon F, Guze L . Use of circulating immune complex levels in the serodifferentiation of endocarditic and nonendocarditic septicemias. Am J Med. 1979; 66(1):58-62. DOI: 10.1016/0002-9343(79)90482-0. View

16.

Kaijser B, Olling S . Experimental hematogenous pyelonephritis due to Escherichia coli in rabbits: the antibody response and its protective capacity. J Infect Dis. 1973; 128(1):41-9. DOI: 10.1093/infdis/128.1.41. View

17.

Fust G, PETRAS G, Ujhelvi E . Activation of the complement system during infections due to gram-negative bacteria. Clin Immunol Immunopathol. 1976; 5(3):293-302. DOI: 10.1016/0090-1229(76)90036-2. View

18.

Bokisch V, Top Jr F, RUSSELL P, Dixon F, MULLER-EBERHARD H . The potential pathogenic role of complement in dengue hemorrhagic shock syndrome. N Engl J Med. 1973; 289(19):996-1000. DOI: 10.1056/NEJM197311082891902. View

19.

Zinner S, McCabe W . Effects of IgM and IgG antibody in patients with bacteremia due to gram-negative bacilli. J Infect Dis. 1976; 133(1):37-45. DOI: 10.1093/infdis/133.1.37. View

20.

Bayer A, Theofilopoulos A, Eisenberg R, Dixon F, Guze L . Circulating immune complexes in infective endocarditis. N Engl J Med. 1976; 295(27):1500-5. DOI: 10.1056/NEJM197612302952703. View