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Glomerular Epithelial Foot Processes in Normal Man and Rats. Distribution of True Width and Its Intra- and Inter-individual Variation

Overview
Journal Cell Tissue Res
Specialties Anatomy & Histology
Cell Biology
Date 1980 Jan 1
PMID 7363304
Citations 26
Authors
H J Gundersen
T Seefeldt
R Osterby
Affiliations
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Abstract

The width of individual glomerular epithelial foot processes appears very different on electron micrographs. A method for obtainining distributions of the true width of foot processes from that of their apparent width on electron micrographs has been developed based on geometric probability theory pertaining to a specific geometric model. Analyses of foot process width in humans and rats show a remarkable interindividual invariance implying rigid control and therefore great biological significance of foot process width or a derivative thereof. The very low inter-individual variation of the true width, shown in the present paper, makes it possible to demonstrate slight changes in rather small groups of patients or experimental animals.

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References
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