Gonadotroph Cell Adenoma of the Pituitary in a Women with Long-standing Hypogonadism

Overview

Journal Arch Gynecol

Publisher Springer

Specialty Gynecology & Obstetrics

Date 1980 Jan 1

PMID 7362277

Citations 9

Authors

K Kovacs

E Horvath

N B Rewcastle

C EZRIN

Affiliations

Soon will be listed here.

Abstract

A 57-year-old woman, with long-standing hypogonadism secondary to irradiation of the ovaries, was found to have a pituitary tumor which was removed and investigated by histology, immunocytology and electron microscopy. Histologically, the tumor corresponded to a chromophobe, slightly PAS positive adenoma and the immunoperoxidase stain revealed the presence of both FSH and LH in the cytoplasm of the adenoma cells. The structural features of the adenoma cells resembled those of FSH cells in the nontumorous adenohypophysis. We thus believe that pituitary adenomas consisting of gonadotrophin-producing cells occur and that these may produce both FSH and LH. The relation between the gonadotrophin-producing adenoma and the preceding hypogonadism is uncertain.

Citing Articles

Insights Obtained from the Nontumorous Glandular Tissue in Patients with Endocrine Tumors.

Tischler A, LiVolsi V, Asa S Endocr Pathol. 2023; 34(4):393-405.

PMID: 36943629 DOI: 10.1007/s12022-023-09759-z.

Functional Gonadotroph Adenomas: Case Series and Report of Literature.

Cote D, Smith T, Sandler C, Gupta T, Bale T, Bi W Neurosurgery. 2015; 79(6):823-831.

PMID: 26692108 PMC: 4912468. DOI: 10.1227/NEU.0000000000001188.

Tumefactive postmenopausal gonadotroph cell hyperplasia.

Jentoft M, Scheithauer B, Moshkin O, Horvath E, Collins P, Syro L Endocr Pathol. 2012; 23(2):108-11.

PMID: 22391975 DOI: 10.1007/s12022-012-9196-9.

The pituitary in Turner syndrome.

Scheithauer B, Kovacs K, Horvath E, Young Jr W, Lloyd R Endocr Pathol. 2005; 16(3):195-200.

PMID: 16299402 DOI: 10.1385/ep:16:3:195.

The pituitary in klinefelter syndrome.

Scheithauer B, Moschopulos M, Kovacs K, Jhaveri B, Percek T, Lloyd R Endocr Pathol. 2005; 16(2):133-8.

PMID: 16199898 DOI: 10.1385/ep:16:2:133.

References

Kovacs K, Horvath E, Van Loon G, Rewcastle N, EZRIN C, ROSENBLOOM A . Pituitary adenomas associated with elevated blood follicle-stimulating hormone levels: a histologic, immunocytologic, and electron microscopic study of two cases. Fertil Steril. 1978; 29(6):622-8. DOI: 10.1016/s0015-0282(16)43333-9. View

CAUGHEY J . The aetiology of pituitary tumours: the role of hypogonadism and hypothyroidism. Australas Ann Med. 1957; 6(2):93-7. DOI: 10.1111/imj.1957.6.2.93. View

Kovacs K, Corenblum B, Sirek A, Penz G, EZRIN C . Localization of prolactin in chromophobe pituitary adenomas: study of human necropsy material by immunoperoxidase technique. J Clin Pathol. 1976; 29(3):250-8. PMC: 476033. DOI: 10.1136/jcp.29.3.250. View

Leong A, Chawla J, Teh E . Pituitary thyrotropic tumour secondary to long-standing primary hypothyroidism. Pathol Eur. 1976; 11(1):49-55. View

DEMURA R, Kubo O, Demura H, SHIZUME K . FSH and LH secreting pituitary adenoma. J Clin Endocrinol Metab. 1977; 45(4):653-7. DOI: 10.1210/jcem-45-4-653. View

Phifer R, Midgley A, SPICER S . Immunohistologic and histologic evidence that follicle-stimulating hormone and luteinizing hormone are present in the same cell type in the human pars distalis. J Clin Endocrinol Metab. 1973; 36(1):125-41. DOI: 10.1210/jcem-36-1-125. View

Gordon S, Moses A . MULTIPLE ENDOCRINE ORGAN REFRACTORINESS TO TROPHIC HORMONE STIMULATION. A PATIENT WITH AN ENLARGED SELLA TURCICA AND INCREASED FSH SECRETION. Ann Intern Med. 1965; 63:313-6. DOI: 10.7326/0003-4819-63-2-313. View

Cunningham G, Huckins C . An FSH and prolactin-secreting pituitary tumor: pituitary dynamics and testicular histology. J Clin Endocrinol Metab. 1977; 44(2):248-53. DOI: 10.1210/jcem-44-2-248. View

Snyder P, Sterling F . Hypersecretion of LH and FSH by a pituitary adenoma. J Clin Endocrinol Metab. 1976; 42(3):544-50. DOI: 10.1210/jcem-42-3-544. View

10.

Woolf P, Schenk E . An FSH-producing pituitary tumor in a patient with hypogonadism. J Clin Endocrinol Metab. 1974; 38(4):561-8. DOI: 10.1210/jcem-38-4-561. View

11.

de Kretser D, Burger H, Dumpys R . Patterns of serum LH and FSH in response to 4-hour infusions of luteinizing hormone releasing hormone in normal women during menstrual cycle, on oral contraceptives, and in postmenopausal state. J Clin Endocrinol Metab. 1978; 46(2):227-35. DOI: 10.1210/jcem-46-2-227. View

12.

LEIBA S, Landau B, BER A . Target gland insufficiency and pituitary tumours. Acta Endocrinol (Copenh). 1969; 60(1):112-20. DOI: 10.1530/acta.0.0600112. View

13.

Von Lawzewitsch I, DICKMANN G, Amezua L, Pardal C . Cytological and ultrastructural characterization of the human pituitary. Acta Anat (Basel). 1972; 81(2):286-316. DOI: 10.1159/000143766. View

14.

KELLY Jr L . Ovarian dwarfism with pituitary tumor. J Clin Endocrinol Metab. 1963; 23:50-3. DOI: 10.1210/jcem-23-1-50. View

15.

MELNYK C, GREER M . FUNCTIONAL PITUITARY TUMOR IN AN ADULT POSSIBLY SECONDARY TO LONG-STANDING MYXEDEMA. J Clin Endocrinol Metab. 1965; 25:761-6. DOI: 10.1210/jcem-25-6-761. View

16.

FRIEND J, JUDGE D, Sherman B, Santen R . FSH-secreting pituitary adenomas: stimulation and suppression studies in two patients. J Clin Endocrinol Metab. 1976; 43(3):650-7. DOI: 10.1210/jcem-43-3-650. View

17.

BALSAM A, OPPENHEIMER J . Pituitary tumor with primary hypothyroidism. Possible etiologic relationship. N Y State J Med. 1975; 75(10):1737-41. View

18.

BOWER B . Pituitary enlargement secondary to untreated primary hypogonadism. Ann Intern Med. 1968; 69(1):107-9. DOI: 10.7326/0003-4819-69-1-107. View

19.

Pelletier G, LECLERC R, Labrie F . Identification of gonadotropic cells in the human pituitary by immunoperoxidase technique. Mol Cell Endocrinol. 1976; 6(2):123-8. DOI: 10.1016/0303-7207(76)90012-5. View

20.

Kovacs K, Horvath E . Gonadotrophs following removal of the ovaries: a fine structural study of human pituitary glands. Endokrinologie. 1975; 66(1):1-8. View