Transfer Factor: a Murine Model

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1980 Jan 1

PMID 7358426

Citations 2

Authors

M E Williams

C A Kauffman

Affiliations

Soon will be listed here.

Abstract

Transfer factor has been studied extensively in humans, but a satisfactory subprimate model has not been established. Using BALB/c mice immunized with complete Freund adjuvant, we show that a low-molecular-weight substance derived from disrupted spleen cells transferred sensitivity to purified protein derivative (PPD) to recipient nonimmunized BALB/c mice. Transfer was confirmed by footpad swelling to PPD in vivo and by splenic lymphocyte transformation to PPD in vitro. In recipients of transfer factor, an inverse correlation was noted between the splenic lymphocyte response to PPD and to concanavalin A. Material obtained from spleens of saline-treated BALB/c mice did not transfer sensitivity to PPD to recipient mice.

Citing Articles

Transfer of Salmonella resistance and delayed hypersensitivity with murine-derived transfer factor.

Smith R, Esa A, STIFF M Infect Immun. 1982; 36(1):271-6.

PMID: 7042572 PMC: 351214. DOI: 10.1128/iai.36.1.271-276.1982.

In vitro effect of murine-derived transfer factor on Salmonella-specific rosette formation.

Smith R, Esa A Infect Immun. 1982; 38(2):588-91.

PMID: 6183216 PMC: 347779. DOI: 10.1128/iai.38.2.588-591.1982.

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