Gall-bladder Sensitivity to Cholecystokinin in Patients with Gall Stones

Overview

Journal Br Med J

Specialty General Medicine

Date 1980 Jan 19

PMID 7357292

Citations 15

Authors

T C Northfield

R M Kupfer

D P Maudgal

P L Zentler-Munro

S T Meller

N W Garvie

R McCready

Affiliations

Soon will be listed here.

Abstract

Gall-bladder sensitivity to cholecystokinin (CCK) was determined by dynamic cholescintigraphy in 18 patients with radiolucent gall stones and 18 matched controls during an infusion of CCK in which the rate of infusion was increased. In 10 of the matched pairs the patient was more sensitive than the control, in one the control was more sensitive, and in seven no difference was detected (p = 0.012). It is concluded that patients with cholesterol gall stones have increased gall-bladder sensitivity to CCK, and that this may be important in the pathogenesis of this disease.

Citing Articles

Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease.

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PMID: 19522027 PMC: 2695892. DOI: 10.3748/wjg.15.2763.

Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis.

Wang D, Schmitz F, Kopin A, Carey M J Clin Invest. 2004; 114(4):521-8.

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Influence of cholecystitis state on pharmacological response to cholecystokinin of isolated human gallbladder with gallstones.

Martinez-Cuesta M, Moreno L, Morillas J, Ponce J, Esplugues J Dig Dis Sci. 2003; 48(5):898-905.

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Effects of ursodiol or ibuprofen on contraction of gallbladder and bile among obese patients during weight loss.

Marks J, Bonorris G, SCHOENFIELD L Dig Dis Sci. 1996; 41(2):242-9.

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Gallbladder motility, gallstones, and the surgeon.

Patankar R, Ozmen M, Bailey I, Johnson C Dig Dis Sci. 1995; 40(11):2323-35.

PMID: 7587810 DOI: 10.1007/BF02063233.

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