Elevated Blood Histamine Levels and Mast Cell Degranulation in Solar Urticaria

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1980 Feb 1

PMID 7356907

Citations 10

Authors

J L Hawk

R A Eady

A V Challoner

T M Keahey

M W Greaves

Affiliations

Soon will be listed here.

Abstract

1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder.

Citing Articles

Solar urticaria: clinical characteristics, treatment effectiveness, long-term prognosis, and QOL status in 29 patients.

Imamura S, Oda Y, Fukumoto T, Mizuno M, Suzuki M, Washio K Front Med (Lausanne). 2024; 11:1328765.

PMID: 38435390 PMC: 10904580. DOI: 10.3389/fmed.2024.1328765.

Evidence for histamine release in chronic inducible urticaria - A systematic review.

Kulthanan K, Church M, Grekowitz E, Hawro T, Kiefer L, Munprom K Front Immunol. 2022; 13:901851.

PMID: 35967442 PMC: 9365951. DOI: 10.3389/fimmu.2022.901851.

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?.

Voss M, Kotrba J, Gaffal E, Katsoulis-Dimitriou K, Dudeck A Int J Mol Sci. 2021; 22(9).

PMID: 33925601 PMC: 8123885. DOI: 10.3390/ijms22094589.

Solar Urticaria.

Komarow H, Eisch A, Young M, Nelson C, Metcalfe D J Allergy Clin Immunol Pract. 2015; 3(5):789-90.

PMID: 25982230 PMC: 4568130. DOI: 10.1016/j.jaip.2015.04.006.

[Solar urticaria].

Schauder S Hautarzt. 2003; 54(10):952-8.

PMID: 14513242 DOI: 10.1007/s00105-003-0579-1.

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