Serotonergic Intraventricular Axons in the Habenular Region. Phagocytosis After Induced Degeneration

Overview

Journal Anat Embryol (Berl)

Specialties Anatomy & Histology
Reproductive Medicine

Date 1980 Jan 1

PMID 7356178

Citations 6

Authors

R N CUPEDO

H de Weerd

Affiliations

Soon will be listed here.

Abstract

Both intracerebroventricular injection of 5,7-dihydroxytryptamine and electrolytical midbrain-raphe lesions in rats induce degeneration of supraependymal axons (SEAs) normally occurring in large numbers upon the ependyma of the medial habenular nucleus and habenular commissure. It is concluded that the intraventricular axon plexus in the epithalamic region is comprised of serotonergic (5-HT) fibers originating in the dorsal and/or median raphe nuclei. Besides the elimination of SEAs, conspicious features were a marked reduction in the number of cilia, degenerative signs in the habenular ependyma, and the emergence of large numbers of supraependymal macrophages, being most probably involved in phagocytosis of the axonal debris. It is suggested that the nucleus habenulae medialis is influenced serotonergically by the midbrain raphe via (1) a direct projection upon its neurons and (2) an indirect projection by way of the intraventricular axon plexus. The origin of intraventricular macrophages is discussed in relation to recent data in the literature.

Citing Articles

Human cerebrospinal fluid increases the excitability of pyramidal neurons in the in vitro brain slice.

Bjorefeldt A, Andreasson U, Daborg J, Riebe I, Wasling P, Zetterberg H J Physiol. 2015; 593(1):231-43.

PMID: 25556798 PMC: 4293065. DOI: 10.1113/jphysiol.2014.284711.

The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review.

Veening J, Barendregt H Cerebrospinal Fluid Res. 2010; 7:1.

PMID: 20157443 PMC: 2821375. DOI: 10.1186/1743-8454-7-1.

Catecholaminergic and serotoninergic fibres innervate the ventricular system of the hedgehog CNS.

Michaloudi H, Papadopoulos G J Anat. 1996; 189 ( Pt 2):273-83.

PMID: 8886949 PMC: 1167744.

Supraependymal cell clusters in the rat hypothalamus.

Martinez Martinez P, de Weerd H Anat Embryol (Berl). 1983; 168(3):371-93.

PMID: 6201088 DOI: 10.1007/BF00304275.

Tanycytes in the medial habenular nucleus of the rat.

CUPEDO R, de Weerd H Anat Embryol (Berl). 1985; 172(1):7-10.

PMID: 4041145 DOI: 10.1007/BF00318938.

References

Leslie R, GWYN D, Morrison C . The fine structure of the ventricular surface of the area postrema of the cat, with particular reference to supraependymal structures. Am J Anat. 1978; 153(2):273-90. DOI: 10.1002/aja.1001530207. View

Gottesfeld Z, Hoover D, Muth E, Jacobowitz D . Lack of biochemical evidence for a direct habenulo-raphe GABAergic pathway. Brain Res. 1978; 141(2):353-6. DOI: 10.1016/0006-8993(78)90205-6. View

Conrad L, Leonard C, Pfaff D . Connections of the median and dorsal raphe nuclei in the rat: an autoradiographic and degeneration study. J Comp Neurol. 1974; 156(2):179-205. DOI: 10.1002/cne.901560205. View

Bobillier P, Seguin S, Petitjean F, Salvert D, Touret M, Jouvet M . The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography. Brain Res. 1976; 113(3):449-86. DOI: 10.1016/0006-8993(76)90050-0. View

Pasquier D, Anderson C, Forbes W, Morgane P . Horseradish peroxidase tracing of the lateral habenular-midbrain raphe nuclei connections in the rat. Brain Res Bull. 1976; 1(5):443-51. DOI: 10.1016/0361-9230(76)90114-3. View

CARPENTER S, MCCARTHY L, BORISON H . Electron microscopic study of the epiplexus (Kolmer) cells of the cat choroid plexus. Z Zellforsch Mikrosk Anat. 1970; 110(4):471-86. DOI: 10.1007/BF00330099. View

Bleier R . Ultrastructure of supraependymal cells and ependyma of hypothalamic third ventricle of mouse. J Comp Neurol. 1977; 174(2):359-76. DOI: 10.1002/cne.901740211. View

Ribas J . The rat epithalamus. I. Correlative scanning-transmission electron microscopy of supraependymal nerves. Cell Tissue Res. 1977; 182(1):1-16. DOI: 10.1007/BF00222050. View

Herkenham M, Nauta W . Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber-of-passage problem. J Comp Neurol. 1977; 173(1):123-46. DOI: 10.1002/cne.901730107. View

10.

Scott D, Paull W, Kozlowski G, Ribas J . The primate median eminence. I. Correlative scanning-transmission electron microscopy. Cell Tissue Res. 1975; 162(1):61-73. DOI: 10.1007/BF00223262. View

11.

Moore R, Halaris A, Jones B . Serotonin neurons of the midbrain raphe: ascending projections. J Comp Neurol. 1978; 180(3):417-38. DOI: 10.1002/cne.901800302. View

12.

PIERCE E, FOOTE W, Hobson J . The efferent connection of the nucleus raphe dorsalis. Brain Res. 1976; 107(1):137-44. DOI: 10.1016/0006-8993(76)90102-5. View

13.

Palkovits M, Saavedra J, Jacoboqitz D, Kizer J, Zaborszky L, Brownstein M . Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain Res. 1977; 130(1):121-34. DOI: 10.1016/0006-8993(77)90847-2. View

14.

Walsh R, Brawer J, Lin P . Supraependymal cells in the third ventricle of the neonatal rat. Anat Rec. 1978; 190(2):257-69. DOI: 10.1002/ar.1091900209. View

15.

LOREZ H, Richards J . Distribution of indolealkylamine nerve terminals in the ventricles of the rat brain. Z Zellforsch Mikrosk Anat. 1973; 144(4):511-22. DOI: 10.1007/BF00307377. View

16.

Wang R, Aghajanian G . Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Res. 1977; 132(1):186-93. DOI: 10.1016/0006-8993(77)90719-3. View

17.

Bleier R . Surface fine structure of supraependymal elements and ependyma of hypothalamic third ventricle of mouse. J Comp Neurol. 1975; 161(4):555-67. DOI: 10.1002/cne.901610406. View

18.

Chan-Palay V . Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity. Brain Res. 1976; 102(1):103-30. DOI: 10.1016/0006-8993(76)90578-3. View

19.

Richards J . Autoradiographic evidence for the selective accumulation of [3H]5-HT by supra-ependymal nerve terminals. Brain Res. 1977; 134(1):151-7. DOI: 10.1016/0006-8993(77)90933-7. View

20.

Breese G, Cooper B . Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats. Brain Res. 1975; 98(3):517-27. PMC: 2913872. DOI: 10.1016/0006-8993(75)90370-4. View