Osteoclasts Derived from Haematopoietic Stem Cells

Overview

Journal Nature

Specialty Science

Date 1980 Feb 14

PMID 7354855

Citations 81

Authors

P Ash

J F LOUTIT

K M Townsend

Affiliations

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Abstract

The origins of the multinucleated osteoclast have been controversial, with osteogenic precursors and haematopoietic stem cells as candidates. Recent evidence for the latter is persuasive but circumstantial. We report here direct evidence obtained in radiation chimaeras from a natural cytoplasmic cell marker transmitted by the donated haematopoietic stem cell.

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