Sister-chromatid Exchanges Induced by Some Chromium Compounds in Human Lymphocytes in Vitro

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1981 Dec 1

PMID 7335108

Citations 4

Authors

S Gomez-Arroyo

M Altamirano

R Villalobos-Pietrini

Affiliations

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Abstract

Treatments with various concentrations of K2Cr2O7, CaCrO4 and CrO3 were given to human lymphocytes cultured in presence of BrdUrd for 2 replicative cycles. Sister-chromatid exchanges (SCEs) were visualized by a combination of fluorescent and Giemsa techniques. In all cases, the higher the concentrations the higher the frequencies of SCEs per metaphase and per chromosome. On a concentration basis, the order of effectiveness in producing SCEs was: CaCrO4 much greater than CrO3 greater than K2Cr2O7.

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