Comparative Toxicity and Tissue Distribution of Lead Acetate in Weanling and Adult Rats

Overview

Journal Environ Health Perspect

Date 1981 Dec 1

PMID 7333253

Citations 6

Authors

J I Rader

J T Peeler

K R Mahaffey

Affiliations

Soon will be listed here.

Abstract

The relative toxicity of low doses of lead acetate provided steadily in drinking water or by mouth once per week was studied in weanling and adult rats. Free erythrocyte protoporphyrin and urinary delta-aminolevulinic acid levels were measured, as well as lead levels in blood and kidney. The accumulation of lead in brain tissue and in bone (femur) was measured to determine the effect of age and schedule of administration on tissue distribution and retention of lead. Total intakes of lead during the 60-week experimental period were: weanling and adult rats exposed to drinking water supplemented with 200 microgram of lead acetate/ml: 127 +/- 10 mg and 160 +/- 16 mg, respectively; weanling and adult rats dosed with lead acetate orally once per week: 132 mg and 161 mg, respectively. Increased toxic effects of lead in the weanling animals were apparent in most of the parameters measured (urinary delta-aminolevulinic acid and blood, brain, femur and kidney lead levels). This pattern was observed in weanling rats exposed to lead steadily through drinking water or dosed orally with an equivalent quantity of lead once per week. Lead levels in blood were highly correlated with the accumulation of lead in brain, femur, and kidney tissue in both groups of weanling rats. In adult rats, significant correlations between blood lead and kidney lead and between blood lead and femur lead were found only in the rats receiving lead steadily in drinking water.

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References

Rosenblum W, Johnson M . Neuropathologic changes produced in suckling mice by adding lead to the maternal diet. Arch Pathol. 1968; 85(6):640-8. View

Barltrop D . Lead poisoning in childhood. Postgrad Med J. 1968; 44(513):537-42. PMC: 2466267. DOI: 10.1136/pgmj.44.513.537. View

Gibson S, GOLDBERG A . Defects in haem synthesis in mammalian tissues in experimental lead poisoning and experimental porphyria. Clin Sci. 1970; 38(1):63-72. DOI: 10.1042/cs0380063. View

Goyer R, Leonard D, Moore J, Rhyne B, Krigman M . Lead dosage and the role of the intranuclear inclusion body. An experimental study. Arch Environ Health. 1970; 20(6):705-11. DOI: 10.1080/00039896.1970.10665647. View

KOSTIAL K, Simonovic I, Pisonic M . Lead absorption from the intestine in newborn rats. Nature. 1971; 233(5321):564. DOI: 10.1038/233564a0. View

FORBES G, Reina J . Effect of age on gastrointestinal absorption (Fe, Sr, Pb) in the rat. J Nutr. 1972; 102(5):647-52. DOI: 10.1093/jn/102.5.647. View

Betts P, ASTLEY R, RAINE D . Lead intoxication in children in Birmingham. Br Med J. 1973; 1(5850):402-6. PMC: 1588291. DOI: 10.1136/bmj.1.5850.402. View

Goyer R, Rhyne B . Pathological effects of lead. Int Rev Exp Pathol. 1973; 12:1-77. View

. Vulnerability of children to lead exposure and toxicity (first of two parts). N Engl J Med. 1973; 289(23):1229-33. DOI: 10.1056/NEJM197312062892306. View

10.

ALEXANDER F . The uptake of lead by children in differing environments. Environ Health Perspect. 1974; 7:155-9. PMC: 1475120. DOI: 10.1289/ehp.747155. View

11.

MICHAELSON I, Sauerhoff M . Animal models of human disease: severe and mild lead encephalopathy in the neonatal rat. Environ Health Perspect. 1974; 7:201-25. PMC: 1475133. DOI: 10.1289/ehp.747201. View

12.

Allen J, McWey P, Suomi S . Pathobiological and behavioral effects of lead intoxication in the infant rhesus monkey. Environ Health Perspect. 1974; 7:239-46. PMC: 1475131. DOI: 10.1289/ehp.747239. View

13.

CHISOLM Jr J, Mellits E, Keil J, Barrett M . Variations in hematologic responses to increased lead absorption in young children. Environ Health Perspect. 1974; 7:7-12. PMC: 1475130. DOI: 10.1289/ehp.7477. View

14.

GOLDSTEIN G, Asbury A, Diamond I . Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries. Arch Neurol. 1974; 31(6):382-9. DOI: 10.1001/archneur.1974.00490420048005. View

15.

Momcilovic B, KOSTIAL K . Kinetics of lead retention and distribution in suckling and adult rats. Environ Res. 1974; 8(2):214-20. DOI: 10.1016/0013-9351(74)90053-x. View

16.

Waldron H . Subclinical lead poisoning: a preventable disease. Prev Med. 1975; 4(2):135-53. DOI: 10.1016/0091-7435(75)90079-1. View

17.

Zook B, London W, Sever J, SAUER R . Experimental lead paint poisoning in nonhuman primates. I. Clinical signs and course. J Med Primatol. 1976; 5(1):23-40. DOI: 10.1159/000459904. View

18.

Chisolm J . Current status of lead exposure and poisoning in children. South Med J. 1976; 69(5):529-31. DOI: 10.1097/00007611-197605000-00001. View

19.

Bull R, Stanaszek P, ONeill J, Lutkenhoff S . Specificity of the effects of lead on brain energy metabolism for substrates donating a cytoplasmic reducing equivalent. Environ Health Perspect. 1975; 12:89-95. PMC: 1475031. DOI: 10.1289/ehp.751289. View

20.

Piomelli S . Free erythrocyte porphyrins in the detection of undue absorption of Pb and of Fe deficiency. Clin Chem. 1977; 23(2 PT. 1):264-9. View