Eczema and Atopy in Early Childhood: Low IgA Plasma Cell Counts in the Jejunal Mucosa

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1981 Dec 1

PMID 7332341

Citations 13

Authors

K S Sloper

C G Brook

D Kingston

J R PEARSON

M SHINER

Affiliations

Soon will be listed here.

Abstract

Twenty-one children aged between 2 and 54 months, 14 with eczema and 7 with allergies in first-degree relatives, were referred for diagnostic jejunal mucosal biopsy for a variety of symptoms. A partial villous atrophy was found in 19 of the 21 biopsies obtained; the other 2 were normal. We report a highly significant (P less than 0.0001) lower IgA cell count in biopsies with partial villous atrophy compared with the results of our previous study of IgA and IgM plasma cells in the mucosal biopsies in children without eczema or a history of atopy matched for age and histological appearances. The IgM cell count was also lower.

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