The Enhancement of Paraquat Toxicity in Rats by 85% Oxygen: Lethality and Cell-specific Lung Damage

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1981 Dec 1

PMID 7326219

Citations 6

Authors

P L Keeling

I S Pratt

W N ALDRIDGE

L L Smith

Affiliations

Soon will be listed here.

Citing Articles

Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain.

Prasad K, Tarasewicz E, Mathew J, Ohman Strickland P, Buckley B, Richardson J Exp Neurol. 2008; 215(2):358-67.

PMID: 19084006 PMC: 4016858. DOI: 10.1016/j.expneurol.2008.11.003.

New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy.

Gharaee-Kermani M, Gyetko M, Hu B, Phan S Pharm Res. 2007; 24(5):819-41.

PMID: 17333393 DOI: 10.1007/s11095-006-9216-x.

Phospholipid synthesis in isolated alveolar type II cells exposed in vitro to paraquat and hyperoxia.

Haagsman H, Schuurmans E, Batenburg J, Van Golde L Biochem J. 1987; 245(1):119-26.

PMID: 3663139 PMC: 1148089. DOI: 10.1042/bj2450119.

Lung surfactant and pulmonary toxicology.

Haagsman H, Van Golde L Lung. 1985; 163(5):275-303.

PMID: 2999522 DOI: 10.1007/BF02713827.

The histopathology of rat lung following exposure to zinc oxide/hexachloroethane smoke or installation with zinc chloride followed by treatment with 70% oxygen.

Brown R, Marrs T, Rice P, Masek L Environ Health Perspect. 1990; 85:81-7.

PMID: 2384070 PMC: 1568343. DOI: 10.1289/ehp.85-1568343.

References

Clark D, MCELLIGOTT T, Hurst E . The toxicity of paraquat. Br J Ind Med. 1966; 23(2):126-32. PMC: 1008384. DOI: 10.1136/oem.23.2.126. View

Wyatt I, Doss A, ZAVALA D, Smith L . Intrabronchial instillation of paraquat in rats: lung morphology and retention study. Br J Ind Med. 1981; 38(1):42-8. PMC: 1008797. DOI: 10.1136/oem.38.1.42. View

Schaffner F, FELIG P, Trachtenberg E . Structure of rat lung after protracted oxygen breathing. Arch Pathol. 1967; 83(1):99-107. View

KISTLER G, CALDWELL P, Weibel E . Development of fine structural damage to alveolar and capillary lining cells in oxygen-poisoned rat lungs. J Cell Biol. 1967; 32(3):605-28. PMC: 2107280. DOI: 10.1083/jcb.32.3.605. View

HAUGAARD N . Cellular mechanisms of oxygen toxicity. Physiol Rev. 1968; 48(2):311-73. DOI: 10.1152/physrev.1968.48.2.311. View

Clark D, Hurst E . The toxicity of diquat. Br J Ind Med. 1970; 27(1):51-5. PMC: 1009041. DOI: 10.1136/oem.27.1.51. View

KAPANCI Y, Weibel E, Kaplan H, ROBINSON F . Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies. Lab Invest. 1969; 20(1):101-18. View

Weibel E . Oxygen effect on lung cells. Arch Intern Med. 1971; 128(1):54-6. View

Vijeyaratnam G, Corrin B . Experimental paraquat poisoning: a histological and electron-optical study of the changes in the lung. J Pathol. 1971; 103(2):123-9. DOI: 10.1002/path.1711030207. View

10.

SHARP C, Ottolenghi A, POSNER H . Correlation of paraquat toxicity with tissue concentrations and weight loss of the rat. Toxicol Appl Pharmacol. 1972; 22(2):241-51. DOI: 10.1016/0041-008x(72)90174-3. View

11.

Fisher H, Clements J, WRIGHT R . Enhancement of oxygen toxicity by the herbicide paraquat. Am Rev Respir Dis. 1973; 107(2):246-52. DOI: 10.1164/arrd.1973.107.2.246. View

12.

Rose M, Smith L, Wyatt I . Evidence for energy-dependent accumulation of paraquat into rat lung. Nature. 1974; 252(5481):314-5. DOI: 10.1038/252314b0. View

13.

Smith P, Heath D . The ultrastructure and time sequence of the early stages of paraquat lung in rats. J Pathol. 1974; 114(4):177-84. DOI: 10.1002/path.1711140402. View

14.

McDowell E, Trump B . Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med. 1976; 100(8):405-14. View

15.

Smith L, Lock E, Rose M . The relationship between 5-hydroxytryptamine and paraquat accumulation into rat lung. Biochem Pharmacol. 1976; 25(22):2485-7. DOI: 10.1016/0006-2952(76)90453-6. View

16.

Sykes B, Purchase I, Smith L . Pulmonary ultrastructure after oral and intravenous dosage of paraquat to rats. J Pathol. 1977; 121(4):233-41. DOI: 10.1002/path.1711210407. View

17.

Douze J, van Heijst A . The paraquat intoxication--oxygen a real poison. Acta Pharmacol Toxicol (Copenh). 1977; 41 Suppl 2:241-5. View

18.

Witschi H, Kacew S, Hirai K, Cote M . In vivo oxidation of reduced nicotinamide-adenine dinucleotide phosphate by paraquat and diquat in rat lung. Chem Biol Interact. 1977; 19(2):143-60. DOI: 10.1016/0009-2797(77)90027-8. View

19.

Kehrer J, Haschek W, Witschi H . The influence of hyperoxia on the acute toxicity of paraquat and diquat. Drug Chem Toxicol. 1979; 2(4):397-408. DOI: 10.3109/01480547909016033. View

20.

Daniel J, Gage J . Absorption and excretion of diquat and paraquat in rats. Br J Ind Med. 1966; 23(2):133-6. PMC: 1008385. DOI: 10.1136/oem.23.2.133. View